INT285644

Context Info Confidence 0.20 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.12 Pain Relevance 0.70

signal transduction (Gpr55) signal transducer activity (Gpr55)

Gpr55 (Mus musculus)

Pain Link Frequency Relevance Heat Cannabinoid 30 99.48 Cannabinoid receptor 13 96.44 Neuronal excitability 1 88.92 Neurotransmitter 1 87.56 antagonist 12 83.72 agonist 31 83.28 Pain 17 73.20 Endocannabinoid 48 64.16 cannabis 2 56.00 Analgesic 17 52.96

Disease Link Frequency Relevance Heat Fever 1 71.28 Nociception 15 50.88 INFLAMMATION 19 45.92 Targeted Disruption 8 44.56 Neuropathic Pain 30 5.00 Pain 26 5.00 Inflammatory Pain 10 5.00 Hyperalgesia 9 5.00 Injury 8 5.00 Urological Neuroanatomy 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A third G protein-coupled receptor, GPR55, binds a number of cannabinoid ligands and, therefore, has been proposed to be a member of the cannabinoid receptor family [[5-8], for review see [9]], although the balance of evidence is not supportive of this classification.

GPR55 Binding (binds) of associated with cannabinoid receptor and cannabinoid

1) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 0.12 Pain Relevance 0.57

Several publications have suggested the orphan receptor GPR55 interacts with certain cannabinoid ligands, including Abn-CBD and O-1602 [55].

GPR55 Binding (interacts) of associated with cannabinoid

2) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0 Pain Relevance 0.13

General Comments

This test has worked.