INT285702

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.40
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tpmt)
Tpmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methotrexate 11 95.68 Very High Very High Very High
corticosteroid 22 80.44 Quite High
Inflammation 43 68.16 Quite High
pruritus 3 67.32 Quite High
Antihistamine 1 21.60 Low Low
cINOD 1 20.80 Low Low
Analgesic 1 19.28 Low Low
headache 7 14.72 Low Low
Demyelination 18 5.00 Very Low Very Low Very Low
Neuritis 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 5 95.44 Very High Very High Very High
Infection 14 94.56 High High
Exanthema 2 92.68 High High
Diarrhoea 2 92.44 High High
Vomiting 9 92.04 High High
Chronic Inflammatory Demyelinating Polyradiculoneuropathy 19 88.60 High High
Hepatotoxicity 2 84.84 Quite High
Congenital Anomalies 2 78.40 Quite High
Eczema 54 75.92 Quite High
Neuropathy 10 69.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homozygous deficiency of TPMT is found in 0.33% of the population, and these individuals are likely to show profound myelosuppression when treated with azathioprine (Meggitt and Reynolds 2001).
Negative_regulation (deficiency) of TPMT
1) Confidence 0.28 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770385 Disease Relevance 0.49 Pain Relevance 0.03
Ten percent of the population is heterozygous and 0.3% homozygous for inability to metabolize azathioprine, and decreased serum thiopurine methyltransferase levels identify these patients [5, 89, 96, 98, 100].
Negative_regulation (decreased) of serum thiopurine methyltransferase
2) Confidence 0.01 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923368 Disease Relevance 0.91 Pain Relevance 0.16

General Comments

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