INT285712

Context Info Confidence 0.23 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.01 Pain Relevance 1.09

cytosol (Set) nucleoplasm (Set) endoplasmic reticulum (Set) nucleus (Set) protein complex (Set) cytoplasm (Set)

Anatomy Link Frequency liver 1 Set (Rattus norvegicus)

Pain Link Frequency Relevance Heat backache 132 99.80 Lasting pain 2 94.72 ischemia 12 57.84 Inflammation 36 51.08 cytokine 15 5.00 Pain 12 5.00 Inflammatory response 6 5.00 Sciatica 6 5.00 Inflammatory mediators 2 5.00 spinal stenosis 2 5.00

Disease Link Frequency Relevance Heat Low Back Pain 134 99.80 Cognitive Disorder 8 95.68 Pain 14 94.72 Injury 12 93.60 Apoptosis 42 78.80 Hepatotoxicity 3 65.56 Death 3 59.84 Reperfusion Injury 8 58.60 INFLAMMATION 43 51.08 Chronic Disease 2 49.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These aspects should therefore be taken into consideration in a revised Comprehensive ICF Core Set.

Localization (revised) of Set

1) Confidence 0.23 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.97 Pain Relevance 0.70

All these considerations also apply to the validation of this ICF Core Set for LBP.

Localization (validation) of Set associated with backache

2) Confidence 0.23 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.34 Pain Relevance 0.34

Importantly, treatment with an inactive form of CORM-2 (iCORM-2), incapable of releasing CO, did not reduce liver I/Ri, indicating that release of CO is important for therapeutic activity (Fig. 1C).

Localization (releasing) of iCORM-2 in liver

3) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.70 Pain Relevance 0.05

General Comments

This test has worked.