INT285725

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.07
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) signal transduction (IGF1R) small molecule metabolic process (INS)
extracellular region (INS) plasma membrane (IGF1R) carbohydrate metabolic process (INS)
IGF1R (Homo sapiens)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 9 99.92 Very High Very High Very High
Pain 3 5.00 Very Low Very Low Very Low
diabetic neuropathy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 93 66.64 Quite High
Hypoglycemia 63 45.68 Quite Low
Obesity 42 5.00 Very Low Very Low Very Low
Weight Gain 42 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Hyperglycemia 6 5.00 Very Low Very Low Very Low
Insulin Resistance 3 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 3 5.00 Very Low Very Low Very Low
Overweight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin detemir has been shown to have a low mitogenic potential and a low IGF-I receptor affinity compared with human insulin (Kurtzhals et al 2000).
IGF-I receptor Binding (affinity) of human insulin
1) Confidence 0.27 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770411 Disease Relevance 0 Pain Relevance 0.13
Insulin detemir has been shown to have a low mitogenic potential and a low IGF-I receptor affinity compared with human insulin (Kurtzhals et al 2000).
IGF-I receptor Binding (affinity) of Insulin
2) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770411 Disease Relevance 0 Pain Relevance 0.13
In vitro studies have demonstrated that the mitogenic potency of insulin analogs mostly correlates with their relative IGF-I receptor binding affinities and/or their rate of dissociation from the insulin receptor; analogs with high affinity for the IGF-I receptor and/or a low dissociation rate from the insulin receptor have increased mitogenic potency.
IGF-I receptor Binding (affinities) of insulin associated with potency
3) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770411 Disease Relevance 0.07 Pain Relevance 0.13

General Comments

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