INT28576

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 5.45
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MLN) cell-cell signaling (MLN)
Anatomy Link Frequency
smooth muscle 3
lamina 3
gastric antrum 2
muscle 1
red blood cells 1
MLN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 42 100.00 Very High Very High Very High
tetrodotoxin 13 98.48 Very High Very High Very High
substance P 1 96.24 Very High Very High Very High
Crohn's disease 100 94.00 High High
agonist 22 89.84 High High
Neuropeptide 7 88.60 High High
antagonist 10 85.72 High High
Pain 8 83.32 Quite High
Morphine 1 81.40 Quite High
cytokine 67 78.88 Quite High
Disease Link Frequency Relevance Heat
Disease 161 100.00 Very High Very High Very High
Inflammatory Bowel Disease 76 100.00 Very High Very High Very High
Renal Failure 1 98.84 Very High Very High Very High
Alzheimer's Dementia 10 97.20 Very High Very High Very High
Parasitemia 6 93.84 High High
Paratuberculosis 80 91.76 High High
Infection 90 87.60 High High
Colitis 276 86.88 High High
Pain 5 83.32 Quite High
Diabetes Mellitus 6 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study confirms that motilin can interact directly with the smooth muscle of human stomach.
motilin Binding (interact) of in stomach
1) Confidence 0.48 Published 1989 Journal Pflugers Arch. Section Abstract Doc Link 2780220 Disease Relevance 0 Pain Relevance 0.10
The aim of this study was to investigate in vitro interactions of motilin with the enteric excitatory neurotransmission in the gastric antrum of the rabbit.
motilin Binding (interactions) of in gastric antrum
2) Confidence 0.48 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9430424 Disease Relevance 0 Pain Relevance 0.07
In conclusion, motilin enhances contractions induced by electrical field stimulation in the rabbit antrum by a post-ganglionic interaction with the cholinergic neurotransmission in vitro at low doses and interacts directly with antral smooth muscle at high doses.
motilin Binding (interacts) of in smooth muscle
3) Confidence 0.48 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9430424 Disease Relevance 0 Pain Relevance 0.20
EM574 displaced specifically 125I-motilin bound to smooth muscle homogenates with a Kd value of 7.8 x 10(-9) M, compared with 4.5 x 10(-9) M for motilin.
125I-motilin Binding (bound) of in smooth muscle
4) Confidence 0.42 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965757 Disease Relevance 0 Pain Relevance 0.17
We investigated the binding of SK-896 to motilin receptors and the contractile effect of SK-896 on smooth muscle preparations isolated from the gastrointestinal tract and various regional organs in order to clarify its in vitro pharmacological profile.
motilin Binding (binding) of in smooth muscle
5) Confidence 0.37 Published 2000 Journal Pharmacology Section Abstract Doc Link 10754449 Disease Relevance 0 Pain Relevance 0.04
We conclude that EM574 directly stimulates smooth muscle cell contraction by acting on motilin receptors in the human gastric antrum in vitro.
motilin Binding (acting) of in gastric antrum
6) Confidence 0.37 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965757 Disease Relevance 0 Pain Relevance 0.15
No pathological consequences of hypermotilemia have been described although elevated motilin levels have been found to be associated with some diarrheal states, renal failure, and in the first week following abdominal surgery.
motilin Binding (associated) of associated with renal failure
7) Confidence 0.37 Published 1984 Journal Life Sci. Section Abstract Doc Link 6381948 Disease Relevance 0.10 Pain Relevance 0.06
MA-2029 concentration-dependently inhibited the binding of [125 I]motilin to motilin receptors in a homogenate of rabbit colon smooth muscle tissue and membranes of HEK 293 cells expressing human motilin receptors.
motilin Binding (binding) of in smooth muscle tissue
8) Confidence 0.36 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18164286 Disease Relevance 0 Pain Relevance 0.20
There is heterogeneity in the motilin receptor affinity for erythromycin in the gastrointestinal tract [28].
motilin Binding (affinity) of
9) Confidence 0.34 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2529327 Disease Relevance 0.13 Pain Relevance 0
EMA was totally ineffective on ileal preparations, which are also unresponsive to motilin and in which motilin binding is absent.
motilin Binding (binding) of
10) Confidence 0.34 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2782416 Disease Relevance 0 Pain Relevance 0.17
Itoh et al. [41] first showed that erythromycin, a macrolide antibiotic, interacts with the motilin receptor and mimicked the effect of motilin on GI motility during the interdigestive state in dogs.
motilin Binding (interacts) of
11) Confidence 0.32 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925306 Disease Relevance 0.21 Pain Relevance 0.03
We have compared the in vitro contractile effect of EMA and two derivatives, 8,9-anhydro-EMA-6,9-hemiketal (EM201) and EMA N-oxide, on rabbit duodenal smooth-muscle strips with their ability to displace iodinated motilin bound to crude smooth-muscle membrane fractions.
motilin Binding (bound) of in muscle
12) Confidence 0.25 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2782416 Disease Relevance 0 Pain Relevance 0.09
This notion is supported by a study by Peeters et al. [34], who described phase III motor activities starting in the stomach or the upper duodenum that are associated with plasma motilin peaks, and another by Lee et al. [35], who reported that immunoneutralization of circulating motilin suppresses phase III contractions.
motilin Binding (associated) of in duodenum
13) Confidence 0.24 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925306 Disease Relevance 0 Pain Relevance 0.03
Group A7 is also composed of receptors for peptide ligands: neuromedin, neurotensin, motilin, endothelin, bombesin and the releasing hormones for growth hormone and thyrotropin.
motilin Binding (ligands) of
14) Confidence 0.15 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.27
chemoattractant; DCs, dendritic cells; IBD, inflammatory bowel disease; JD, Johne's disease; LP, lamina propria; MLN, mesenteric lymph nodes; pDCs, plasmacytoid dendritic cells; PP, Peyer's patches; SAA, serum amyloid A; TLR, toll-like receptor; UC, ulcerative colitis.


MLN Binding (chemoattractant) of in lamina associated with inflammatory bowel disease, inflammation, alzheimer's dementia and disease
15) Confidence 0.03 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.34 Pain Relevance 0.18
Spleens and MLN from individual mice were mechanically dissociated, and red blood cells were lysed with ACK lysis buffer (Sigma), 14 weeks after challenge.
MLN Binding (dissociated) of in red blood cells
16) Confidence 0.03 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.24 Pain Relevance 0.08
chemoattractant; DCs, dendritic cells; IBD, inflammatory bowel disease; JD, Johne's disease; LP, lamina propria; MLN, mesenteric lymph nodes; pDCs, plasmacytoid dendritic cells; PP, Peyer's patches; SAA, serum amyloid A; TLR, toll-like receptor; UC, ulcerative colitis.


MLN Binding (mesenteric lymph nodes) of in lamina associated with inflammatory bowel disease, inflammation, alzheimer's dementia and disease
17) Confidence 0.03 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.30 Pain Relevance 0.17
chemoattractant; DCs, dendritic cells; IBD, inflammatory bowel disease; JD, Johne's disease; LP, lamina propria; MLN, mesenteric lymph nodes; pDCs, plasmacytoid dendritic cells; PP, Peyer's patches; SAA, serum amyloid A; TLR, toll-like receptor; UC, ulcerative colitis.


MLN Binding (dendritic cells) of in lamina associated with inflammatory bowel disease, inflammation, alzheimer's dementia and disease
18) Confidence 0.03 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.33 Pain Relevance 0.17
Very little information is available regarding the immunological response of chronic chagasic patients with gastrointestinal forms of the disease, and none of these works analyze gut-associated lymphoid tissues or MLN.
MLN Binding (associated) of in lymphoid tissues associated with disease
19) Confidence 0.02 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.73 Pain Relevance 0.08

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