INT28578

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.49
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (B4galt4) Golgi apparatus (B4galt4) carbohydrate metabolic process (B4galt4)
Anatomy Link Frequency
spinal nerve 1
tail 1
internal 1
dorsal horn 1
B4galt4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 6 99.20 Very High Very High Very High
Spinal cord 9 98.92 Very High Very High Very High
Peripheral nerve injury 4 98.24 Very High Very High Very High
tail-flick 3 97.84 Very High Very High Very High
Intracerebroventricular 4 97.72 Very High Very High Very High
agonist 5 94.00 High High
intrathecal 7 93.28 High High
Dorsal horn neuron 1 93.04 High High
Spinal nerve ligature 6 90.96 High High
substance P 3 86.48 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 98.24 Very High Very High Very High
Hypertension 2 93.56 High High
Nociception 4 90.16 High High
Experimental Autoimmune Neuritis 12 87.48 High High
Injury 4 79.60 Quite High
Sprains And Strains 2 71.44 Quite High
Heart Rate Under Development 1 48.24 Quite Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of intraventricular injection of beta-casomorphin-4, morphiceptin and deltakephalin (DTLET) on hot water tail flick and tail compression responses were investigated in Wistar Albino Glaxo (WAG) and spontaneously hypertensive rats (SHR).
Gene_expression (injection) of beta-casomorphin-4 in tail associated with hypertension and tail-flick
1) Confidence 0.67 Published 1989 Journal Peptides Section Abstract Doc Link 2780414 Disease Relevance 0.24 Pain Relevance 0.36
RESULTS: The expression of beta4 decreased in the acute phase P<0.05 and showed no significant changes in the recovery phase(P=0.6840).
Gene_expression (expression) of beta4
2) Confidence 0.06 Published 2003 Journal Beijing Da Xue Xue Bao Section Body Doc Link 14710253 Disease Relevance 0.09 Pain Relevance 0
The changes of expression of integrin alpha6 and beta4 in EAN were confirmed by semi-quantitative PT-PCR, using GAPDH as the internal standard.
Gene_expression (expression) of beta4 in internal
3) Confidence 0.06 Published 2003 Journal Zhonghua Bing Li Xue Za Zhi Section Body Doc Link 12882692 Disease Relevance 0.15 Pain Relevance 0
RESULTS: The detection of integrin alpha6 and beta4 subunit by hybridization in situ demonstrated that expression of alpha6 subunit present no significant changes during the course of EAN, while expression of beta4 declined in the early phase, showing less positive signals than those of the control, and restored its expression in the later or recovery phase.
Gene_expression (expression) of beta4
4) Confidence 0.05 Published 2003 Journal Zhonghua Bing Li Xue Za Zhi Section Body Doc Link 12882692 Disease Relevance 0.16 Pain Relevance 0
The expression changes of alpha6 and beta4 correlate with the injury and repair of myelin during EAN.


Gene_expression (expression) of beta4
5) Confidence 0.05 Published 2003 Journal Beijing Da Xue Xue Bao Section Body Doc Link 14710253 Disease Relevance 0.06 Pain Relevance 0
Intracerebroventricular (icv) beta-casomorphin1-7 (beta-CM1-7) stimulated intake of HF diet in overnight fasted rats, but beta-CM1-5 and beta-CM1-4 were ineffective.
Gene_expression (ineffective) of beta-CM1-4 associated with intracerebroventricular
6) Confidence 0.02 Published 1998 Journal Peptides Section Abstract Doc Link 9493865 Disease Relevance 0 Pain Relevance 0.31
The expression of the alpha4, alpha7, beta2, beta3 and beta4 subunits was unchanged.
Gene_expression (expression) of beta4
7) Confidence 0.01 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 14741388 Disease Relevance 0.37 Pain Relevance 0.55
We examined the expression of the alpha3, alpha4, alpha5, alpha7, beta2, beta3 and beta4 nicotinic subunits in the spinal cord of normal and spinal nerve ligated rats using immunocytochemistry.
Spec (examined) Gene_expression (expression) of beta4 in spinal nerve associated with spinal cord
8) Confidence 0.01 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 14741388 Disease Relevance 0.43 Pain Relevance 0.52
In the dorsal spinal cord, confocal immunohistochemical microscopy revealed that nAChR subunits (alpha3, alpha4, alpha5, beta2 and beta4), NeuN B (neuronal marker) and NK1-r were all co-expressed in the superficial dorsal horn; however alpha3, alpha5, beta2 and beta4 exhibited the highest degree of colocalization with NK1-r expressing neurons.
Gene_expression (co-expressed) of beta4 in dorsal horn associated with dorsal horn and spinal cord
9) Confidence 0.01 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18037142 Disease Relevance 0 Pain Relevance 0.74

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