INT285818

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.18
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.14
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1H2) nucleus (NR1H2) DNA binding (NR1H2)
cytoplasm (NR1H2)
NR1H2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 12 92.24 High High
Paracetamol 10 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 8 71.76 Quite High
Cancer 28 5.00 Very Low Very Low Very Low
Nicotine Addiction 22 5.00 Very Low Very Low Very Low
Bladder Cancer 16 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Transitional Cell Carcinoma 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In two cell lines both expressing CYP1A2 and NAT2, but one deficient in NER, 2,6-DMA and 3,5-DMA were cytotoxic and mutagenic at dose levels between 100 ?
Negative_regulation (deficient) of NER
1) Confidence 0.18 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.07 Pain Relevance 0.09
The influence of NER status was investigated by comparison of responses of AA8 CHO cells, which are NER proficient, and UV5 cells, which are NER deficient.
Negative_regulation (deficient) of NER
2) Confidence 0.13 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.07 Pain Relevance 0.03
We added hydroxyurea and cytosine arabinocide to cells to prevent NER polymerization and ligation of any incised SSBs after mitomycin C exposures, and then used the alkaline DNA unwinding assay, which detects SSBs (27).
Negative_regulation (prevent) of NER
3) Confidence 0.03 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2770670 Disease Relevance 0 Pain Relevance 0
The NER polymerization step is inhibited using hydroxyurea (2 mM) and cytosine arabinocide (20 ┬ÁM).
Negative_regulation (inhibited) of NER
4) Confidence 0.03 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2770670 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox