INT28583

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Context Info
Confidence 0.06
First Reported 1985
Last Reported 1989
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.34
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atp7b) Golgi apparatus (Atp7b) plasma membrane (Atp7b)
Anatomy Link Frequency
platelet 6
body 2
Atp7b (Mus musculus)
Pain Link Frequency Relevance Heat
Regional anesthesia 3 100.00 Very High Very High Very High
local anesthetic 6 99.84 Very High Very High Very High
lidocaine 6 98.70 Very High Very High Very High
Serotonin 6 98.52 Very High Very High Very High
anesthesia 15 95.04 Very High Very High Very High
epidural 12 94.60 High High
cINOD 1 90.88 High High
Disease Link Frequency Relevance Heat
Injury 3 97.48 Very High Very High Very High
Bacterial Respiratory Disease 2 75.00 Quite High
Fever 1 75.00 Quite High
Toxicity 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In in vitro studies, only low concentrations of lidocaine (0.5-1.0 micrograms/ml) and bupivacaine (0.5-3.0 micrograms/ml) increased platelet TxB2 production.
Positive_regulation (increased) of Gene_expression (production) of TxB2 in platelet associated with lidocaine
1) Confidence 0.06 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2780766 Disease Relevance 0 Pain Relevance 1.00
The results suggest that the increased TxB2 plasma levels and platelet TxB2 production during regional anesthesia are not caused by local anesthetics itself but by other factors, e.g. tissue trauma.
Positive_regulation (increased) of Gene_expression (production) of TxB2 in platelet associated with injury, regional anesthesia and local anesthetic
2) Confidence 0.04 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2780766 Disease Relevance 0.10 Pain Relevance 0.99
The results suggest that the increased TxB2 plasma levels and platelet TxB2 production during regional anesthesia are not caused by local anesthetics itself but by other factors, e.g. tissue trauma.
Neg (not) Positive_regulation (caused) of Gene_expression (production) of TxB2 in platelet associated with injury, regional anesthesia and local anesthetic
3) Confidence 0.04 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2780766 Disease Relevance 0.10 Pain Relevance 0.99
Ibuprofen effectively suppressed endotoxin-induced increases in the plasma levels of TxB2, 6-keto-PGF1 alpha, PGF2 alpha, and serotonin and body temperature.
Positive_regulation (increases) of Gene_expression (levels) of TxB2 in body associated with serotonin
4) Confidence 0.00 Published 1985 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 3867760 Disease Relevance 0.15 Pain Relevance 0.26

General Comments

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