INT285898

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL4) extracellular space (CCL4) extracellular region (CCL4)
cell adhesion (CCL4) cell-cell signaling (CCL4)
Anatomy Link Frequency
microglia 4
CCL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 36 100.00 Very High Very High Very High
Inflammation 68 96.80 Very High Very High Very High
cytokine 34 82.32 Quite High
Inflammatory stimuli 2 80.40 Quite High
Central nervous system 30 53.44 Quite High
Inflammatory mediators 14 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 90 96.80 Very High Very High Very High
Neurodegenerative Disease 20 92.24 High High
Apoptosis 112 79.00 Quite High
Lyme Disease 26 50.00 Quite Low
Neuroblastoma 10 5.00 Very Low Very Low Very Low
Lyme Neuroborreliosis 10 5.00 Very Low Very Low Very Low
Infection 10 5.00 Very Low Very Low Very Low
Multiple Sclerosis 10 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Bites And Stings 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Potent and sustained expression of the chemokines CCL2, CCL3, CCL4 and CCL5, in addition to that of IL-6 and IL-8, contributes to maintaining the inflammatory environment created by microglia in response to B. burgdorferi
Negative_regulation (Potent) of Gene_expression (expression) of CCL4 in microglia associated with chemokine and inflammation
1) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.48 Pain Relevance 0.21
Potent and sustained expression of the chemokines CCL2, CCL3, CCL4 and CCL5, in addition to that of IL-6 and IL-8, contributes to maintaining the inflammatory environment created by microglia in response to B. burgdorferi
Negative_regulation (sustained) of Gene_expression (expression) of CCL4 in microglia associated with chemokine and inflammation
2) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.48 Pain Relevance 0.21

General Comments

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