INT285904

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCL2L1) mitochondrion (BCL2L1) growth (BCL2L1)
cytoskeleton (BCL2L1) nucleus (BCL2L1) intracellular (BCL2L1)
BCL2L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 68 78.24 Quite High
Inflammatory mediators 14 71.64 Quite High
Inflammatory response 6 45.84 Quite Low
Central nervous system 30 36.88 Quite Low
chemokine 36 27.68 Quite Low
Multiple sclerosis 4 10.00 Low Low
cytokine 34 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 112 100.00 Very High Very High Very High
INFLAMMATION 90 78.24 Quite High
Infection 10 55.84 Quite High
Lyme Disease 26 50.00 Quite Low
Multiple Sclerosis 10 15.44 Low Low
Cancer 2 14.56 Low Low
Neurodegenerative Disease 20 5.00 Very Low Very Low Very Low
Neuroblastoma 10 5.00 Very Low Very Low Very Low
Lyme Neuroborreliosis 10 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This conclusion was founded on the observed upregulation in transcripts for AKT1 and Bcl-XL, paired with decreased gene expression for DRAM.
Positive_regulation (upregulation) of Transcription (transcripts) of Bcl-XL
1) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.60 Pain Relevance 0.13
In cultures containing only SY cells and B. burgdorferi, there were prominent increases in transcript for the cell survival and anti-apoptotic molecules protein kinase B (AKT1) and BCL2-like (Bcl-XL) genes, combined with a decrease in transcript for pro-apoptotic damage-regulated autophagy modulator (DRAM) (Table 6-left, Figure 4A).
Positive_regulation (increases) of Transcription (transcript) of Bcl-XL associated with apoptosis
2) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.35 Pain Relevance 0

General Comments

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