INT285935

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.68
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (POU5F1) aging (IL6) DNA binding (POU5F1)
cytoplasm (POU5F1) cytosol (POU5F1) extracellular space (IL6)
Anatomy Link Frequency
stem cell 2
IL6 (Homo sapiens)
POU5F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 153 87.52 High High
cytokine 81 83.56 Quite High
chemokine 12 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Keloid Scars 309 93.80 High High
Cancer 84 89.92 High High
INFLAMMATION 162 87.52 High High
Disease 48 86.32 High High
Fibrosis 9 85.96 High High
Benign Tumor 51 65.52 Quite High
Malignant Neoplastic Disease 9 63.56 Quite High
Aging 9 53.36 Quite High
Cicatrix 21 5.00 Very Low Very Low Very Low
Injury 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, our results show that IL-6 can significantly stimulate the expression of both Oct-4 and telomerase, two important stem cell function genes, in cultured KPCs and SKPs, and incubation with specific IL-6 neutralizing antibodies suppressed the constitutive expression of telomerase in KPCs.
IL-6 Positive_regulation (stimulate) of Gene_expression (expression) of Oct-4 in stem cell
1) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 1.55 Pain Relevance 0.31
Similar to IL-6, IL-17 enhanced hTERT and Oct-4 expression in both SKPs and KPCs (Figure 5B).
IL-6 Positive_regulation (enhanced) of Gene_expression (expression) of Oct-4
2) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.09 Pain Relevance 0
We have demonstrated that IL-6 stimulates the expression of Oct-4 and telomerase in vivo and significantly promotes the growth of KPCs and SKPs-generated transplants.
IL-6 Positive_regulation (stimulates) of Gene_expression (expression) of Oct-4
3) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 1.04 Pain Relevance 0.07

General Comments

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