INT285940

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.42
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, IL17A) extracellular region (IL6, IL17A) cell death (IL17A)
aging (IL6) cell-cell signaling (IL17A)
IL6 (Homo sapiens)
IL17A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 54 92.12 High High
Inflammation 102 91.72 High High
Inflammatory mediators 4 86.96 High High
chemokine 8 78.68 Quite High
Multiple sclerosis 4 64.60 Quite High
psoriasis 2 63.80 Quite High
rheumatoid arthritis 4 63.36 Quite High
Inflammatory response 4 21.48 Low Low
fibrosis 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Keloid Scars 206 96.80 Very High Very High Very High
Hypersensitivity 4 96.80 Very High Very High Very High
Disease 32 96.44 Very High Very High Very High
INFLAMMATION 108 91.72 High High
Adhesions 2 84.88 Quite High
Necrosis 2 77.16 Quite High
Cancer 56 76.80 Quite High
Allergic Dermatitis 2 65.36 Quite High
Demyelinating Disease 4 64.60 Quite High
Psoriasis 2 63.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More importantly, IL-6 not only functions downstream of IL-17 but also acts as a critical upstream target of IL-17, thus forming a paracrine/autocrine feedback loop that promotes autoimmune and allergic diseases [50], [51].
IL-6 Binding (target) of IL-17 associated with hypersensitivity and disease
1) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 1.32 Pain Relevance 0.53
We then explored the interaction between IL-6 and IL-17 and determine whether the IL-17/IL-6 axis contributes to the regulation of the keloid niche.
IL-6 Spec (determine) Binding (interaction) of IL-17 associated with keloid scars
2) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.10 Pain Relevance 0

General Comments

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