INT285943

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.02
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL17A, IL6) extracellular region (IL17A, IL6) aging (IL6)
cell death (IL17A) cell-cell signaling (IL17A)
Anatomy Link Frequency
fibroblasts 2
epithelial cells 2
T cells 2
IL17A (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 81 99.84 Very High Very High Very High
cytokine 67 98.76 Very High Very High Very High
Inflammation 124 98.72 Very High Very High Very High
Inflammatory stimuli 2 85.80 High High
fibrosis 6 60.40 Quite High
chemokine 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 79 99.84 Very High Very High Very High
INFLAMMATION 133 98.72 Very High Very High Very High
Injury 12 92.84 High High
Infection 4 90.08 High High
Intraoperative Complications 4 89.52 High High
Benign Tumor 34 88.64 High High
Keloid Scars 206 82.56 Quite High
Disease 70 62.64 Quite High
Fibrosis 8 60.40 Quite High
Cancer 56 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, IL-17 induces the secretion of IL-6 in a variety of cells including fibroblasts [44], [50] and epithelial cells [51].
IL-17 Positive_regulation (induces) of Localization (secretion) of IL-6 in epithelial cells
1) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.08 Pain Relevance 0
1, may trigger the differentiation of naïve T cells into TH17 cells, which further stimulate IL-6 secretion via IL-17, thus creating an enriched pro-inflammatory cytokine milieu.
IL-17 Positive_regulation (stimulate) of Localization (secretion) of IL-6 in T cells associated with inflammation and cytokine
2) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 1.50 Pain Relevance 0.35
Some RA synovial fibroblasts spontaneously produced VEGF-A, however VEGF-A production was significantly increased by rIL-17 even at low concentrations (1 ng/ml). rIL-17 at higher concentrations also significantly induced IL-6 secretion by RA synovial fibroblasts, a cytokine involved in both inflammation and angiogenesis (reviewed in [27]).
rIL-17 Positive_regulation (induced) of Localization (secretion) of IL-6 in fibroblasts associated with inflammation, cytokine and arthritis
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.44 Pain Relevance 0.30

General Comments

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