INT285947

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, IL17A) extracellular region (IL6, IL17A) cell death (IL17A)
aging (IL6) cell-cell signaling (IL17A)
Anatomy Link Frequency
stem cells 1
IL6 (Homo sapiens)
IL17A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 51 98.32 Very High Very High Very High
cytokine 27 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 54 98.32 Very High Very High Very High
Keloid Scars 103 97.44 Very High Very High Very High
Cancer 28 50.00 Quite Low
Apoptosis 2 14.56 Low Low
Benign Tumor 17 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Cicatrix 7 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Fibrosis 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results provide further evidence that IL-6, as a downstream target of IL-17 and an essential component of the unique inflammatory niche of keloid, plays a critical role in the regulation of self-renewal and differentiation of keloid stem cells.
IL-6 Regulation (target) of IL-17 in stem cells associated with inflammation and keloid scars
1) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.44 Pain Relevance 0.05

General Comments

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