INT285979

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.18
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) nucleolus (Trib3)
nucleus (Trib3) plasma membrane (Ros1) enzyme binding (Trib3)
Ros1 (Rattus norvegicus)
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 2 88.52 High High
Kinase C 10 82.76 Quite High
ischemia 21 82.72 Quite High
Bioavailability 5 76.48 Quite High
Inflammation 9 16.08 Low Low
antagonist 7 6.40 Low Low
cva 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 45 99.48 Very High Very High Very High
Myocardial Reperfusion Injury 12 99.46 Very High Very High Very High
Death 4 85.24 High High
Cv Unclassified Under Development 10 82.72 Quite High
Coronary Heart Disease 1 80.24 Quite High
Diabetes Complications 3 79.32 Quite High
Necrosis 6 78.52 Quite High
Reperfusion Injury 12 77.44 Quite High
Diabetes Mellitus 29 71.28 Quite High
Stress 15 71.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, reactive oxygen species (ROS) are formed in excessive amounts within the first few minutes following reperfusion and are considered important to myocardial reperfusion injury.5) In addition, excessive ROS during the early stages of reperfusion increases the activity of mitogen-activated protein (MAP) kinase and induces apoptosis following reperfusion.6-8)
ROS Positive_regulation (increases) of kinase associated with myocardial reperfusion injury and apoptosis
1) Confidence 0.02 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 1.41 Pain Relevance 0.08
ROS activate p38 kinase, which further promotes ROS generation, forming a positive feedback loop to sustain ROS-p38 kinase signaling, which may associate with a reduction in SIRT1 protein expression.
ROS Positive_regulation (activate) of kinase
2) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.77 Pain Relevance 0.12

General Comments

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