INT286035

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 6.20
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
spinal cord 2
Tp53 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 8 99.36 Very High Very High Very High
ischemia 38 99.12 Very High Very High Very High
fibrosis 14 83.20 Quite High
Inflammation 46 77.04 Quite High
depression 4 35.36 Quite Low
cva 48 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Sciatic nerve 8 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Thoracotomy 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 104 100.00 Very High Very High Very High
Cv Unclassified Under Development 34 99.12 Very High Very High Very High
Death 49 96.24 Very High Very High Very High
Stress 25 95.40 Very High Very High Very High
Diabetes Mellitus 55 95.08 Very High Very High Very High
Myocardial Infarction 78 94.60 High High
Hypothermia 276 93.92 High High
Cancer 44 91.80 High High
Hemorrhagic Shock 36 91.60 High High
Malignant Neoplastic Disease 4 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a rabbit model of ischemia-reperfusion, hypothermic animals exhibited decreased expression of pro-apoptotic proteins, transformation-related protein (p53) and bak, and an increased expression of anti-apoptotic Bcl-2 homologue Bcl-x [100].
Negative_regulation (decreased) of Gene_expression (expression) of transformation-related protein associated with ischemia and apoptosis
1) Confidence 0.32 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.68 Pain Relevance 0.14
Sirt1 protein overexpression was further associated with a decrease in p53 acetylation in GK rats postligation.
Negative_regulation (decrease) of Gene_expression (acetylation) of p53
2) Confidence 0.25 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.64 Pain Relevance 0.17
In a rabbit model of ischemia-reperfusion, hypothermic animals exhibited decreased expression of pro-apoptotic proteins, transformation-related protein (p53) and bak, and an increased expression of anti-apoptotic Bcl-2 homologue Bcl-x [100].
Negative_regulation (decreased) of Gene_expression (expression) of p53 associated with ischemia and apoptosis
3) Confidence 0.23 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.69 Pain Relevance 0.14
In addition, PARP-1 deficient cell lines exhibit a significant reduction in both baseline p53 expression and its activity compared to normal wild type cells [150].
Negative_regulation (reduction) of Gene_expression (expression) of p53
4) Confidence 0.06 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.45 Pain Relevance 0
Here, we showed that p53 expression is relatively
               low in the DRG and spinal cord, and did not undergo significant changes upon axotomy
               in animals. 
Negative_regulation (low) of Gene_expression (expression) of p53 in spinal cord associated with spinal cord
5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.74 Pain Relevance 0.05

General Comments

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