INT286042

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.05
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tp53, Wwox) nucleus (Tp53, Wwox) enzyme binding (Tp53, Wwox)
cytoplasm (Tp53, Wwox) cytosol (Tp53, Wwox) nucleoplasm (Tp53)
Anatomy Link Frequency
nerve 1
Tp53 (Rattus norvegicus)
Wwox (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 32 96.88 Very High Very High Very High
Sciatic nerve 32 80.08 Quite High
ketamine 4 72.16 Quite High
Neuropathic pain 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 76 100.00 Very High Very High Very High
Targeted Disruption 16 99.76 Very High Very High Very High
Apoptosis 116 99.12 Very High Very High Very High
Nervous System Injury 8 98.60 Very High Very High Very High
Lung Cancer 4 91.32 High High
Injury 64 88.68 High High
Necrosis 4 76.56 Quite High
Cancer 28 76.20 Quite High
Neuroblastoma 36 70.16 Quite High
Ganglion Cysts 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
WOX1 is essential for p53-mediated cell death through binding and stabilizing
               phosphorylated p53 [7]. 
p53 Binding (binding) of WOX1 associated with death
1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.78 Pain Relevance 0.05
So far, we have no
               direct evidence showing that p53 and WOX1 physically interact during peripheral
               nerve injury. 
p53 Binding (interact) of WOX1 in nerve associated with nervous system injury
2) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.68 Pain Relevance 0.04
WOX1 physically interacts with p53 in cultured cells [6]–[8],
                       [13]. 
p53 Binding (interacts) of WOX1
3) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.33 Pain Relevance 0.14
WOX1 may physically interact with p53 and JNK1 to regulate apoptosis in
                       vitro and in vivo
                   [6]–[8], [13],
                       [15], [16]. 
p53 Binding (interact) of WOX1 associated with apoptosis
4) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.26 Pain Relevance 0.05

General Comments

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