INT286045

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.33
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun, Wwox) nucleus (Jun, Wwox) mitochondrion (Wwox)
aging (Jun) Golgi apparatus (Wwox) enzyme binding (Wwox)
Anatomy Link Frequency
neurons 2
SK-N-SH 1
Jun (Rattus norvegicus)
Wwox (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 48 70.24 Quite High
Sciatic nerve 48 66.32 Quite High
ketamine 6 5.00 Very Low Very Low Very Low
Neuropathic pain 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 54 98.28 Very High Very High Very High
Apoptosis 174 97.76 Very High Very High Very High
Nervous System Injury 12 89.68 High High
Injury 96 81.96 Quite High
Ganglion Cysts 6 75.00 Quite High
Repression 6 66.76 Quite High
Death 114 63.48 Quite High
Neurodegenerative Disease 24 55.96 Quite High
Lung Cancer 6 53.00 Quite High
Cancer 42 51.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we demonstrated mouse WOX1 physically interacted with p-c-Jun in the
               injured neurons in rat DRGs, and enhanced the promoter activation governed by c-Jun
                   in vivo. 
Jun Binding (interacted) of WOX1 in neurons
1) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.41 Pain Relevance 0
We confirmed these observations by immuno-EM, and
               showed the complex formation of WOX1 with c-Jun on day 3rd post axotomy in rats.
               
Jun Binding (formation) of WOX1
2) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.58 Pain Relevance 0.03
By immunoprecipitation, we showed that WOX1 binds CREB and c-Jun in non-stimulated
               SK-N-SH neuroblastoma cells. 
Jun Binding (binds) of WOX1 in SK-N-SH associated with neuroblastoma
3) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.59 Pain Relevance 0.04
Colocalization of p-WOX1 with p-c-Jun was shown mainly in the nuclei 6 hours
                   after axotomy, whereas no apparent binding of p-WOX1 with c-Jun was found (large
                   particles for p-c-Jun; small particles for p-WOX1; Supporting Fig.
                   
Jun Neg (no) Binding (binding) of p-WOX1
4) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.12 Pain Relevance 0
S9a–c). 3 days later, complex formation of p-WOX1 and
                   p-c-Jun was shown in many small neurons (Supporting Fig. 
Jun Binding (formation) of p-WOX1 in neurons
5) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.16 Pain Relevance 0
Immunoelectron microscopy revealed the complex formation of p-WOX1
                       with p-CREB and p-c-Jun in vivo. 
Jun Binding (formation) of p-WOX1
6) Confidence 0.08 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2771921 Disease Relevance 0.46 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox