INT286067

Context Info Confidence 0.37 First Reported 2008 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.21 Pain Relevance 0.05

extracellular space (Igf1) extracellular region (Igf1)

Anatomy Link Frequency podocytes 2 Igf1 (Mus musculus)

Pain Link Frequency Relevance Heat Bioavailability 1 100.00 tolerance 17 25.20 alcohol 2 5.00 Chronic pancreatitis 1 5.00 anesthesia 1 5.00 Angina 1 5.00 agonist 1 5.00 Kinase C 1 5.00 isoflurane 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 19 97.96 Metabolic Syndrome 11 59.24 Insulin Resistance 14 50.00 Disorder Of Lipid Metabolism 15 47.60 Hypoglycemia 1 40.00 Hyperinsulinism 3 36.16 Impaired Glucose Tolerance 17 25.20 Cancer 7 5.00 Ocular Toxicity (including Many Sub-types) 5 5.00 Diabetic Retinopathy 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To determine whether IGF-1-mediated regulation of splicing was apparent at the protein level, podocytes were incubated with the pharmacological inhibitors of PKC (BIMI), and ELISA carried out on the protein extracted from the cells.

Spec (whether) Regulation (apparent) of Spec (whether) Regulation (regulation) of IGF-1-mediated in podocytes

1) Confidence 0.37 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0

In this regard, a polymorphism in the promoter region of the IGF-I gene was associated with low levels of IGF-I and increased risk of type-2 diabetes mellitus.[21] In addition to this, IGF-I binding proteins (IGFBPs) were not measured, which play an important role in regulating the bioavailability of IGF-I.

Regulation (role) of Regulation (regulating) of IGF-I associated with diabetes mellitus and bioavailability

2) Confidence 0.25 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.21 Pain Relevance 0.05

General Comments

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