INT286068

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.03
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
liver 2
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 26 99.28 Very High Very High Very High
dorsal root ganglion 1 74.56 Quite High
tolerance 17 69.00 Quite High
Inflammation 20 42.32 Quite Low
Multiple sclerosis 28 41.52 Quite Low
Bioavailability 1 14.40 Low Low
Action potential 29 5.00 Very Low Very Low Very Low
Spinal cord 18 5.00 Very Low Very Low Very Low
Nav1.6 11 5.00 Very Low Very Low Very Low
Dorsal column 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 11 99.60 Very High Very High Very High
Demyelinating Disease 59 99.28 Very High Very High Very High
Disorder Of Lipid Metabolism 15 91.40 High High
Cv Unclassified Under Development 1 78.20 Quite High
Insulin Resistance 14 75.88 Quite High
Ganglion Cysts 1 74.56 Quite High
Impaired Glucose Tolerance 17 69.00 Quite High
Diabetes Mellitus 19 68.36 Quite High
Multiple Sclerosis 217 56.16 Quite High
INFLAMMATION 21 42.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, low levels of serum IGF-I were significantly related with the metabolic syndrome according to the World Health Organization.[19] However, our findings are consistent with the animal studies demonstrating low insulin sensitivity in mice with liver specific deletion of the IGF-I gene that is reversed by treatment with recombinant human IGF-I.[34] Raised blood pressure and slightly enhanced plasma insulin concentrations have been reported in mice with a mutant IGF-I allele causing a marked decrease in circulating IGF-I levels.[20]
Positive_regulation (related) of Positive_regulation (levels) of serum IGF-I in liver associated with metabolic syndrome
1) Confidence 0.40 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.64 Pain Relevance 0.03
Oestradiol is known to induce an increase in insulin-like growth factor-1 during cuprizone demyelination (Acs et al., 2009).
Positive_regulation (induce) of Positive_regulation (increase) of insulin-like growth factor-1 associated with demyelination
2) Confidence 0.23 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.39 Pain Relevance 0.13

General Comments

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