INT286068

Context Info Confidence 0.40 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.03 Pain Relevance 0.16

extracellular space (Igf1) extracellular region (Igf1)

Anatomy Link Frequency liver 2 Igf1 (Mus musculus)

Pain Link Frequency Relevance Heat Demyelination 26 99.28 dorsal root ganglion 1 74.56 tolerance 17 69.00 Inflammation 20 42.32 Multiple sclerosis 28 41.52 Bioavailability 1 14.40 Action potential 29 5.00 Spinal cord 18 5.00 Nav1.6 11 5.00 Dorsal column 5 5.00

Disease Link Frequency Relevance Heat Metabolic Syndrome 11 99.60 Demyelinating Disease 59 99.28 Disorder Of Lipid Metabolism 15 91.40 Cv Unclassified Under Development 1 78.20 Insulin Resistance 14 75.88 Ganglion Cysts 1 74.56 Impaired Glucose Tolerance 17 69.00 Diabetes Mellitus 19 68.36 Multiple Sclerosis 217 56.16 INFLAMMATION 21 42.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, low levels of serum IGF-I were significantly related with the metabolic syndrome according to the World Health Organization.[19] However, our findings are consistent with the animal studies demonstrating low insulin sensitivity in mice with liver specific deletion of the IGF-I gene that is reversed by treatment with recombinant human IGF-I.[34] Raised blood pressure and slightly enhanced plasma insulin concentrations have been reported in mice with a mutant IGF-I allele causing a marked decrease in circulating IGF-I levels.[20]

Positive_regulation (related) of Positive_regulation (levels) of serum IGF-I in liver associated with metabolic syndrome

1) Confidence 0.40 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.64 Pain Relevance 0.03

Oestradiol is known to induce an increase in insulin-like growth factor-1 during cuprizone demyelination (Acs et al., 2009).

Positive_regulation (induce) of Positive_regulation (increase) of insulin-like growth factor-1 associated with demyelination

2) Confidence 0.23 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.39 Pain Relevance 0.13

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