INT286071

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.69
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1, Ins1) extracellular region (Igf1, Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
blood 1
Igf1 (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 1 88.02 High High
tolerance 17 79.04 Quite High
Chronic pancreatitis 1 37.68 Quite Low
alcohol 1 32.32 Quite Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 3 98.92 Very High Very High Very High
Atherosclerosis 2 98.42 Very High Very High Very High
Diabetes Mellitus 19 98.00 Very High Very High Very High
Insulin Resistance 14 97.80 Very High Very High Very High
Metabolic Syndrome 11 97.30 Very High Very High Very High
Myocardial Infarction 1 94.82 High High
Syndrome 1 89.52 High High
Cv General 3 Under Development 1 88.02 High High
Hyperinsulinism 3 80.60 Quite High
Impaired Glucose Tolerance 17 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animals with absence of liver specific IGF-I gene are characterized by hyperinsulinemia and skeletal muscle insulin resistance.[34] These animals when treated with recombinant IGF-I showed a reduction in insulin levels and an increase in insulin sensitivity.[3] Clinical studies performed in patients with extreme insulin resistance and in patients with both types of diabetes have shown that recombinant IGF-I administration significantly lowered blood glucose and increased insulin sensitivity.[5–8] A recent study concluded that low concentrations of IGF-I in the blood circulation was increasingly associated with increased risk of developing type-2 diabetes.[9] In nondiabetic subjects, the low levels of IGF-I in circulation have been associated with angiographically reported coronary artery diseases.[1011] In patients with effort angina pectoris and angiographically normal epicardial coronary arteries (cardiac syndrome-X), low levels of IGF-I have been observed.[12] Individuals with low levels of IGF-I have increased risk of developing ischemic heart disease compared to individuals with normal levels of IGF-I.[13] Nondiabetic patients succumbing to an acute myocardial infarction had significantly lower IGF-I levels than survivors.[14] In view of these findings, a close link between metabolic syndrome-X and insulin resistance, diabetes, and atherosclerotic coronary artery diseases might be attributed to the low levels of circulating IGF-I, which in turn affects insulin sensitivity.
IGF-I Regulation (affects) of insulin in blood associated with angina, coronary artery disease, atherosclerosis, syndrome, diabetes mellitus, metabolic syndrome, insulin resistance, hyperinsulinism and myocardial infarction
1) Confidence 0.10 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 1.69 Pain Relevance 0.20

General Comments

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