INT286082

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Acvr2a)
Anatomy Link Frequency
brain 2
Acvr2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 15 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retina Disease 33 99.64 Very High Very High Very High
Ganglion Cysts 9 99.52 Very High Very High Very High
Targeted Disruption 63 87.36 High High
Night Blindness 3 76.00 Quite High
Disease 3 66.36 Quite High
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Sunburn 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the transfer of the ChR2 gene into RGCs was not regulated according to RGC type in these studies, it is possible that all RGC types became photosensitive.
Positive_regulation (transfer) of Gene_expression (transfer) of ChR2
1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.32 Pain Relevance 0
In addition, Bi et al. reported that the transfer of ChR2 restored visually evoked cortical responses in blind mice [8].
Positive_regulation (transfer) of Gene_expression (transfer) of ChR2
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.51 Pain Relevance 0
If the ChR2 gene is transferred to retinal ganglion cells (RGCs), which send visual information to the brain, the RGCs may be repurposed to act as photoreceptors.
Positive_regulation (transferred) of Gene_expression (transferred) of ChR2 in brain associated with ganglion cysts
3) Confidence 0.04 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2772120 Disease Relevance 0.43 Pain Relevance 0

General Comments

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