INT286082

Context Info Confidence 0.06 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.25 Pain Relevance 0

cytoplasm (Acvr2a)

Anatomy Link Frequency brain 2 Acvr2a (Rattus norvegicus)

Pain Link Frequency Relevance Heat Action potential 15 5.00 anesthesia 6 5.00 addiction 3 5.00 ketamine 3 5.00 Glutamate receptor 3 5.00

Disease Link Frequency Relevance Heat Retina Disease 33 99.64 Ganglion Cysts 9 99.52 Targeted Disruption 63 87.36 Night Blindness 3 76.00 Disease 3 66.36 Sprains And Strains 6 5.00 Apoptosis 6 5.00 Death 3 5.00 Sunburn 3 5.00 Stress 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since the transfer of the ChR2 gene into RGCs was not regulated according to RGC type in these studies, it is possible that all RGC types became photosensitive.

Positive_regulation (transfer) of Gene_expression (transfer) of ChR2

1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.32 Pain Relevance 0

In addition, Bi et al. reported that the transfer of ChR2 restored visually evoked cortical responses in blind mice [8].

Positive_regulation (transfer) of Gene_expression (transfer) of ChR2

2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.51 Pain Relevance 0

If the ChR2 gene is transferred to retinal ganglion cells (RGCs), which send visual information to the brain, the RGCs may be repurposed to act as photoreceptors.

Positive_regulation (transferred) of Gene_expression (transferred) of ChR2 in brain associated with ganglion cysts

3) Confidence 0.04 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2772120 Disease Relevance 0.43 Pain Relevance 0

General Comments

This test has worked.