INT28609

Context Info Confidence 0.41 First Reported 1989 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.07 Pain Relevance 0.38

extracellular region (MLN) cell-cell signaling (MLN)

Anatomy Link Frequency smooth muscle tissue 2 MLN (Homo sapiens)

Pain Link Frequency Relevance Heat substance P 1 96.80 tetrodotoxin 1 91.20 agonist 2 90.64 antagonist 3 86.28 Visceral pain 2 75.00 Pain 2 25.00 spastic colon 1 25.00

Disease Link Frequency Relevance Heat Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 2 75.00 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 1 33.60 Functional Bowel Disorder 1 5.00 Gastrointestinal Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MA-2029 concentration-dependently inhibited the binding of [125 I]motilin to motilin receptors in a homogenate of rabbit colon smooth muscle tissue and membranes of HEK 293 cells expressing human motilin receptors.

Negative_regulation (inhibited) of motilin Binding (binding) of in smooth muscle tissue

1) Confidence 0.41 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18164286 Disease Relevance 0 Pain Relevance 0.20

EMA was totally ineffective on ileal preparations, which are also unresponsive to motilin and in which motilin binding is absent.

Negative_regulation (absent) of motilin Binding (binding) of

2) Confidence 0.31 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2782416 Disease Relevance 0 Pain Relevance 0.17

General Comments

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