INT28609

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Context Info
Confidence 0.41
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MLN) cell-cell signaling (MLN)
Anatomy Link Frequency
smooth muscle tissue 2
MLN (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 1 96.80 Very High Very High Very High
tetrodotoxin 1 91.20 High High
agonist 2 90.64 High High
antagonist 3 86.28 High High
Visceral pain 2 75.00 Quite High
Pain 2 25.00 Low Low
spastic colon 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 75.00 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 33.60 Quite Low
Functional Bowel Disorder 1 5.00 Very Low Very Low Very Low
Gastrointestinal Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MA-2029 concentration-dependently inhibited the binding of [125 I]motilin to motilin receptors in a homogenate of rabbit colon smooth muscle tissue and membranes of HEK 293 cells expressing human motilin receptors.
Negative_regulation (inhibited) of motilin Binding (binding) of in smooth muscle tissue
1) Confidence 0.41 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18164286 Disease Relevance 0 Pain Relevance 0.20
EMA was totally ineffective on ileal preparations, which are also unresponsive to motilin and in which motilin binding is absent.
Negative_regulation (absent) of motilin Binding (binding) of
2) Confidence 0.31 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2782416 Disease Relevance 0 Pain Relevance 0.17

General Comments

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