INT286102

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Context Info
Confidence 0.30
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 8.58
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Fap) extracellular space (Fap) plasma membrane (Fap)
Anatomy Link Frequency
germline 1
Fap (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 8 81.52 Quite High
imagery 20 5.00 Very Low Very Low Very Low
Bile 16 5.00 Very Low Very Low Very Low
Central nervous system 14 5.00 Very Low Very Low Very Low
abdominal pain 12 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 1035 100.00 Very High Very High Very High
Syndrome 64 100.00 Very High Very High Very High
Disease 152 99.36 Very High Very High Very High
Intestinal Cancer 4 99.04 Very High Very High Very High
Adenoma 244 96.60 Very High Very High Very High
Polyps 285 95.12 Very High Very High Very High
Colon Cancer 185 92.60 High High
Adenomatous Polyps 50 87.84 High High
Stress 5 87.60 High High
Hereditary Nonpolyposis Colorectal Neoplasms 17 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Attenuated FAP is a milder form of FAP
Positive_regulation (Attenuated) of FAP associated with familial adenomatous polyposis
1) Confidence 0.30 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.70 Pain Relevance 0
Attenuated FAP
Positive_regulation (Attenuated) of FAP associated with familial adenomatous polyposis
2) Confidence 0.30 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.58 Pain Relevance 0.04
FAP is caused by a highly heterogeneous spectrum of point mutations and this represents a problem for molecular genetic diagnosis; all the mutations are chain terminating.
Positive_regulation (caused) of FAP associated with familial adenomatous polyposis
3) Confidence 0.28 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.59 Pain Relevance 0
FAP is a dominant syndrome caused when one copy of the APC gene contains a fault; this means that every child of a FAP patient has a 50% chance of inheriting the faulty gene.
Positive_regulation (caused) of FAP associated with syndrome and familial adenomatous polyposis
4) Confidence 0.28 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 2.05 Pain Relevance 0
Since the identification of the APC gene and the presence of a naturally occurring autosomal dominantly transmitted mouse equivalent of FAP (known as the Multiple Intestinal Neoplasia or Min mouse) harboring a germline mutation in the mouse Apc gene (written Apc to designate mouse) questions concerning disease expression and penetrance could be addressed.
Positive_regulation (equivalent) of FAP in germline associated with familial adenomatous polyposis, intestinal cancer and disease
5) Confidence 0.24 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 1.65 Pain Relevance 0

General Comments

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