INT286104

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mutyh) hydrolase activity, acting on glycosyl bonds (Mutyh) nucleus (Mutyh)
Mutyh (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 5.00 Very Low Very Low Very Low
Bile 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
abdominal pain 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 66 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 480 99.62 Very High Very High Very High
Apoptosis 2 94.60 High High
Adenoma 116 94.40 High High
Adhesions 6 94.16 High High
Polyps 136 88.48 High High
Hyperplasia 6 86.08 High High
Cancer 132 80.60 Quite High
Colorectal Cancer 2 71.08 Quite High
Adenocarcinoma 18 68.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We estimate that a mutation in the APC gene will be more severe then mutation in the MUTYH gene, as the APC gene is part of the Wnt pathway and can influence several cellular functions such as proliferation, differentiation, apoptosis, adhesion, migration, and chromosomal segregation.
Negative_regulation (severe) of MUTYH associated with familial adenomatous polyposis, apoptosis and adhesions
1) Confidence 0.35 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0.95 Pain Relevance 0
MUTYH associated polyposis is a frequent inherited CRC predisposition, which can be mostly in a recessive form of inheritance (bi-allelic or compound mutations) but also as a dominant component, and therefore DNA screening of the MUTYH gene should look for both heterozygous and homozygous mutations [46].
Negative_regulation (predisposition) of MUTYH associated with colon cancer
2) Confidence 0.31 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.30 Pain Relevance 0

General Comments

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