INT286173

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 0.49
Pain Relevance 0.03

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peptidase activity (ADAMTS2) extracellular region (ADAMTS2) proteinaceous extracellular matrix (ADAMTS2)
ADAMTS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 6 54.08 Quite High
headache 1 42.32 Quite Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
nMDA receptor 5 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 55 98.80 Very High Very High Very High
Adhesions 18 97.52 Very High Very High Very High
Hyperinsulinism 6 71.36 Quite High
Diarrhoea 1 43.48 Quite Low
Headache 1 42.32 Quite Low
Hallucination 3 40.96 Quite Low
Influenza Virus Infection 1 40.84 Quite Low
Injury 2 39.88 Quite Low
Dizziness 1 38.52 Quite Low
Aggression 8 34.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gauthier et al investigated the effect of memantine on the behavioral symptoms in AD in a pooled analysis of 6 RCTs.52 The outcome was based on NPI scores, which were defined by 2 categories: (1) symptom improvement: assessed in patients who displayed the symptom at baseline, and (2) symptom emergence: assessed in patients who did not have the symptom at baseline.
Gene_expression (scores) of NPI associated with disease
1) Confidence 0.13 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2773287 Disease Relevance 0.23 Pain Relevance 0
Whole cellular extracts were prepared as follows: cells obtained from NPI monolayers were resuspended in 100??
Gene_expression (obtained) of NPI
2) Confidence 0.04 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
NPI/T25 flask) were cocultured for 7, 14, 21 days with microencapsulated SC in Click's medium (Sigma Chemical Co) supplemented with 10% fetal bovine serum (EuroClone, Wetherby, UK), 0.5% bovine serum albumin, fraction V (BSA) (Sigma Chemical Co), 10?
Gene_expression (flask) of NPI
3) Confidence 0.04 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
-cells, (Figure 4) declined progressively in the NPI cell monolayers cocultured with ESC, as compared to untreated NPI cell monolayers however, difference was statistically significant only for the 21 day-treated NPI (P < .050); (b) the percentage of NPI double positive for PDX-1/insulin, a mature  ?
Gene_expression (treated) of NPI
4) Confidence 0.04 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
No appreciable morphological differences were detectable between NPI monolayers cultivated alone (data not shown) and those cocultivated with ESC throughout day 21.
Gene_expression (detectable) of NPI
5) Confidence 0.04 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0.19 Pain Relevance 0
Different samples of control (untreated) NPI cell monolayers and ESC cocultured NPI underwent double immunostaining with different couples of primary antibodies, namely: Ck7/Insulin (Figure 4), PDX-1/Insulin (Figure 5), PDX-1/c-kit (Figure 6), Insulin+/c-kit (Figure 7).
Gene_expression (underwent) of NPI
6) Confidence 0.04 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0.07 Pain Relevance 0
qPCR analysis, reported by Figure 9, showed statistically significant differences in the expression of a number of genes between treated and untreated NPI.
Gene_expression (expression) of NPI
7) Confidence 0.03 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0.03

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