INT286196

Context Info Confidence 0.36 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.95 Pain Relevance 0.33

peptidase activity (Psmb9) nucleus (Psmb9) cytoplasm (Psmb9)

Psmb9 (Mus musculus)

Pain Link Frequency Relevance Heat spinal inflammation 2 91.36 psoriasis 2 87.52 midbrain 26 86.00 alcohol 2 78.96 Inflammation 16 76.00 Sicca syndrome 2 72.56 Glutamate 10 5.00 Ventral tegmentum 7 5.00 monoamine 5 5.00 cytokine 5 5.00

Disease Link Frequency Relevance Heat Autoimmune Disease 14 99.84 Disease 96 92.40 Low Back Pain 2 91.36 Hashimoto Disease 30 90.60 Stress 11 90.36 Hypopigmentation 2 89.04 Hypothyroidism 32 88.92 Psoriasis 2 87.52 INFLAMMATION 17 76.00 Systemic Lupus Erythematosus 2 75.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

After blocking aspecific binding with 5% normal goat serum, sections were incubated with the primary antibody; rabbit anti proteasome subunit (LMP2, LMP7, LMP10, PA28?

LMP2 Binding (subunit) of

1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 0 Pain Relevance 0.04

Some studies have positively linked LMP2 to autoimmunity.

LMP2 Binding (linked) of associated with autoimmune disease

2) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.42 Pain Relevance 0.21

Parkin interacts with the 26S proteosome through its ubiquitin ligase domain facilitating the recognition of ubiquitinated substrates by the proteasomal activator PA700 (Pickart, 2004).

proteosome Binding (interacts) of

3) Confidence 0.36 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.53 Pain Relevance 0.08

General Comments

This test has worked.