INT286198

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.95
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Psmb9) nucleus (Psmb9) cytoplasm (Psmb9)
Psmb9 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 15 55.92 Quite High
cytokine 3 5.00 Very Low Very Low Very Low
Sicca syndrome 3 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypothyroidism 48 99.32 Very High Very High Very High
Targeted Disruption 150 96.00 Very High Very High Very High
Autoimmune Disease 21 94.16 High High
Thyroiditis 9 86.48 High High
Body Weight 3 85.32 High High
Carcinoma 24 84.44 Quite High
Increased Venous Pressure Under Development 3 79.56 Quite High
Apoptosis 12 78.32 Quite High
Hyperthyroidism 18 77.88 Quite High
Hyperlipidemia 3 75.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LMP2 deficiency by itself had no influence on circulating T4 levels (Figure 4D, third group) or growth (Figure 4E, third group).
Negative_regulation (deficiency) of LMP2
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 0.80 Pain Relevance 0
Interestingly, the lack of LMP2 ameliorated the hypothyroidism seen in thyr-IFN?
Negative_regulation (lack) of LMP2 associated with hypothyroidism
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.29 Pain Relevance 0.03
Mice lacking only LMP2 (Figure S3, second group) also had a significantly lower radioiodine accumulation than wild type controls, in keeping with the flattened thyrocyte morphology previously described (Figure S2A).
Negative_regulation (lacking) of LMP2
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 0.86 Pain Relevance 0

General Comments

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