INT28620

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Context Info
Confidence 0.40
First Reported 1989
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk, Crh) extracellular space (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
nerve 1
Penk (Rattus norvegicus)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 7 100.00 Very High Very High Very High
Nerve growth factor 1 100.00 Very High Very High Very High
Opioid 1 85.88 High High
tetrodotoxin 1 83.84 Quite High
narcan 2 79.80 Quite High
antagonist 2 79.44 Quite High
opioid receptor 1 79.00 Quite High
Disease Link Frequency Relevance Heat
Hypertension 3 95.48 Very High Very High Very High
Stress 4 75.00 Quite High
Sprains And Strains 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of immobilization on the expression of immediate-early gene c-fos and nerve growth factor-inducible (NGFI)-B mRNAs, corticotropin-releasing factor (CRF) mRNA, CRF heteronuclear RNA (hnRNA), CRF receptor types 1 and 2alpha mRNA, and enkephalin hn/mRNA were investigated in the hypothalamic paraventricular nucleus of Wistar-Kyoto (WKY) rats and borderline hypertensive rats (BHRs).
enkephalin Regulation (effects) of CRF in nerve associated with nerve growth factor, hypertension and enkephalin
1) Confidence 0.40 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9523573 Disease Relevance 0.25 Pain Relevance 0.29
However, a significant increase in the basal release of this peptide was observed 4 weeks after gonadectomy, and the Met-ENK-releasing efficacy of CRH was found to be reduced.
Met-ENK Regulation (efficacy) of CRH
2) Confidence 0.26 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2783452 Disease Relevance 0 Pain Relevance 0.46

General Comments

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