INT286247

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Context Info
Confidence 0.70
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.41
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Calcrl) endosome (Calcrl) signal transduction (Calcrl)
endoplasmic reticulum (Calcrl) plasma membrane (Calcrl) lysosome (Calcrl)
Anatomy Link Frequency
muscle 4
outflow 2
Calcrl (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 84.92 Quite High
antagonist 3 54.88 Quite High
eye pain 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 9 98.88 Very High Very High Very High
Glaucoma 135 98.56 Very High Very High Very High
Ocular Hypertension 24 98.52 Very High Very High Very High
Targeted Disruption 9 97.76 Very High Very High Very High
Congenital Anomalies 3 97.40 Very High Very High Very High
Paralysis 6 97.36 Very High Very High Very High
Disease 6 73.76 Quite High
Scotoma 3 18.32 Low Low
Blindness 6 5.84 Low Low
Cardiovascular Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that overexpression of CALCRL can lead to increased sensitivity of the sphincter muscle to endogenous AM, thus causing chronic relaxation of the sphincter muscle and, as a consequence, obstruction of the aqueous outflow system.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CALCRL in outflow
1) Confidence 0.70 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773738 Disease Relevance 0.67 Pain Relevance 0.03
However mice that overexpressed CALCRL in smooth muscle-containing tissues had increased CALCRL/RAMP2 (AM receptors) in the pupillary sphincter muscle, resulting in enhanced AM-induced sphincter muscle relaxation.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CALCRL in muscle
2) Confidence 0.61 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773738 Disease Relevance 0.49 Pain Relevance 0
Overexpression of calcitonin receptor-like receptor (CALCRL) in the pupillary sphincter muscle resulted in pupillary palsy and acutely and transiently elevated IOP in mice, mimicking the characteristic phenotype of acute PACG in humans.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of calcitonin receptor-like receptor in muscle associated with glaucoma, ocular hypertension and paralysis
3) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773738 Disease Relevance 1.25 Pain Relevance 0.04

General Comments

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