INT286316

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.10
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Aph1a) Golgi apparatus (Aph1a) endoplasmic reticulum (Aph1a)
Anatomy Link Frequency
fibroblasts 1
Aph1a (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 30 64.28 Quite High
cINOD 6 50.88 Quite High
Disease Link Frequency Relevance Heat
Disease 30 98.74 Very High Very High Very High
Alzheimer's Dementia 33 50.00 Quite Low
Infection 9 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Viral Infection 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the lifetime of the GFP-donor was significantly shorter in the Aph1B containing cells, compared to that in fibroblasts expressing Aph1A or wild-type Aph1 (Table 4).
Gene_expression (expressing) of Aph1A in fibroblasts
1) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0.05
These manipulations include introducing familial Alzheimer's disease L166P PS1 mutation, structural change in the Pen2 N-terminus, expressing Aph1B or Aph1A isoform, or pharmacological treatment (fenofibrate, ibuprofen).
Gene_expression (expressing) of Aph1A associated with disease
2) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.10 Pain Relevance 0.03
MEF cells expressing either all Aph1 isoforms (wt Aph1), or exclusively Aph1A or Aph1B containing ?
Gene_expression (containing) of Aph1A
3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0

General Comments

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