INT286326

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.26
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
Notch 2
cleavage 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 2 98.64 Very High Very High Very High
Neuronal excitability 2 56.24 Quite High
Glutamate 1 52.64 Quite High
Calcium channel 1 8.56 Low Low
imagery 10 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 92.00 High High
Disease 52 88.72 High High
Alzheimer's Dementia 18 50.00 Quite Low
Death 5 17.04 Low Low
Amnesia 1 10.72 Low Low
Drug Induced Neurotoxicity 3 9.76 Low Low
Neurodegenerative Disease 3 8.76 Low Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Syndrome 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a similar fashion, released AICD has been shown to possess transactivation activity and can regulate transcription of multiple genes including APP, GSK-3?
Regulation (regulate) of Transcription (transcription) of APP
1) Confidence 0.45 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.17 Pain Relevance 0
Like NICD (Notch intracellular domain), several recent studies have suggested that AICD has transactivation activity and can regulate transcription of multiple genes including APP, GSK-3?
Regulation (regulate) of Transcription (transcription) of APP in Notch
2) Confidence 0.44 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2935165 Disease Relevance 0 Pain Relevance 0.05
-secretase cleavage site on APP from the A?
Regulation (on) of Transcription (site) of APP in cleavage
3) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.09 Pain Relevance 0.10

General Comments

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