INT286336

Context Info Confidence 0.10 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.39 Pain Relevance 0

peptidase activity (PSENEN) Golgi apparatus (PSENEN) endoplasmic reticulum (PSENEN) plasma membrane (PSENEN)

PSENEN (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 20 5.00 cINOD 4 5.00

Disease Link Frequency Relevance Heat Disease 20 92.00 Alzheimer's Dementia 22 85.04 Toxicity 2 83.80 Targeted Disruption 2 40.56 Infection 6 5.00 Death 2 5.00 Aging 2 5.00 Viral Infection 2 5.00 INFLAMMATION 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data show directly that changes in PS1 conformation can be detected following various manipulations of PS1 itself, Pen2, Aph1, APP, and pharmacological agents known as ?

Positive_regulation (manipulations) of Gene_expression (itself) of Pen2

1) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.15 Pain Relevance 0

We found that in the conditioned media of the flag-Pen2 transfected cells the A?

Positive_regulation (transfected) of Gene_expression (transfected) of Pen2

2) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.23 Pain Relevance 0

General Comments

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