INT286343

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) oxidoreductase activity (Snca)
histone binding (Snca) plasma membrane (Snca) cytoskeleton (Snca)
Anatomy Link Frequency
DA neurons 2
Snca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 28 98.88 Very High Very High Very High
cva 1 76.96 Quite High
medulla 1 71.44 Quite High
midbrain 8 58.32 Quite High
Ventral tegmentum 16 5.00 Very Low Very Low Very Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 7 98.72 Very High Very High Very High
Disease 54 93.40 High High
Hemorrhage 1 76.96 Quite High
Stress 5 60.00 Quite High
Pressure And Volume Under Development 2 19.96 Low Low
Nerve Degeneration 1 8.00 Low Low
Parkinson's Disease 19 5.00 Very Low Very Low Very Low
Hypokinesia 5 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, these models are of limited value due to some significant limitations, such as a rapid loss of DA neurons, a failure to induce typical brain lesions, an absence of alpha-synuclein expression, and the potential of systemic toxicity.
Negative_regulation (absence) of Gene_expression (expression) of alpha-synuclein in DA neurons associated with toxicity and dopamine
1) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774159 Disease Relevance 0.65 Pain Relevance 0.15

General Comments

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