INT286344

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.84
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) oxidoreductase activity (Snca)
histone binding (Snca) plasma membrane (Snca) cytoskeleton (Snca)
Anatomy Link Frequency
neurons 2
brain 2
Snca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
midbrain 40 99.46 Very High Very High Very High
Dopamine 140 98.66 Very High Very High Very High
Ventral tegmentum 80 88.20 High High
Substantia nigra 20 86.80 High High
depression 5 54.16 Quite High
cva 5 35.72 Quite Low
medulla 5 30.20 Quite Low
anesthesia 15 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 270 97.08 Very High Very High Very High
Toxicity 35 93.20 High High
Death 20 92.80 High High
Pressure And Volume Under Development 10 84.00 Quite High
Stress 25 80.48 Quite High
Nerve Degeneration 5 67.20 Quite High
Neurodegenerative Disease 10 64.72 Quite High
Depression 5 54.16 Quite High
Hemorrhage 5 35.72 Quite Low
Parkinson's Disease 95 29.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the double-immunohistostaining study suggested that rotenone-induced alpha-synuclein expression was increased in a dose-dependent manner.
Positive_regulation (induced) of Gene_expression (expression) of alpha-synuclein
1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774159 Disease Relevance 0.65 Pain Relevance 0.23
Moreover, the double-immunohistostaining study suggested that rotenone-induced alpha-synuclein expression was increased in a dose-dependent manner.
Positive_regulation (increased) of Gene_expression (expression) of alpha-synuclein
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774159 Disease Relevance 0.65 Pain Relevance 0.23
The double immunohistostaining of alpha-synuclein and TH showed a dose-dependent decrease in the number of TH-positive neurons, an increase in alpha-synuclein expression in the lesioned brain (Figure 5).
Positive_regulation (increase) of Gene_expression (expression) of alpha-synuclein in brain
3) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774159 Disease Relevance 0.31 Pain Relevance 0.16
The rotenone infusion also reduced the DA content, the glutathione and superoxide dismutase activities, and induced alpha-synuclein expression, when compared to the contralateral side.
Positive_regulation (induced) of Gene_expression (expression) of alpha-synuclein associated with dopamine
4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2774159 Disease Relevance 0.49 Pain Relevance 0.25
In summary, the main features of our current model include: 1) a one-time, low-dose ST infusion of rotenone could generate a characteristic decrease in the nigrostriatal TH immunoreactivity; 2) APO-induced rotations progressed gradually until the 24th week; 3) rotenone depleted DA, but not 5-HT at the beginning in the low-dose groups; 4) the GSH and SOD activities were lowered, and the generation of MDA was increased in the midbrain treated with rotenone; 5) alpha-synuclein expression was increased, and TH-positive neurons were decreased, both in a dose-dependent fashion; 6) the infused SNc developed characteristic ultrastructural changes of abnormal mitochondria; 7) the SYS model can reproduce the typical behaviors of PD but is associated with peripheral toxicity; and 8) after rotenone infusion for four weeks, all the ST model rats and ten of the twelve SYS models showed representative behavioral features of PD.
Positive_regulation (increased) of Gene_expression (expression) of alpha-synuclein in neurons associated with toxicity, dopamine, midbrain and disease
5) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774159 Disease Relevance 0.74 Pain Relevance 0.17

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