INT286346

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (IL8) DNA binding (IRF6) cytoplasm (IRF6)
cytosol (IRF6) extracellular space (IL8) signal transduction (IL8)
Anatomy Link Frequency
amnion 1
IRF6 (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 112 96.48 Very High Very High Very High
Inflammation 77 96.08 Very High Very High Very High
Inflammatory stimuli 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 94 96.08 Very High Very High Very High
Toxicity 1 83.20 Quite High
Necrosis 5 79.00 Quite High
Cancer 5 78.64 Quite High
Candida Infection 2 67.20 Quite High
Pre-term Labor 8 57.68 Quite High
Infection 28 41.76 Quite Low
Disease 4 40.48 Quite Low
Skin Diseases 4 34.88 Quite Low
Purpura 6 10.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, LPS treatment of the amnion side failed to increase IL-10 or IL-8 on the amniotic side of the membranes yet increased IL-10 and IL-8 on the choriodecidual side, indicating that the inflammatory signal, but not the cytokine itself, most likely propagated across the membranes from the amnion to the choriodecidua.
LPS Neg (failed) Positive_regulation (increase) of IL-8 in amnion associated with inflammation and cytokine
1) Confidence 0.03 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.37 Pain Relevance 0.31
from human gestational membranes in Transwell cultures [23], and show for the first time that releases of IL-6, IL-8 and IL-10 are stimulated by LPS in a side-specific manner from human gestational membranes.
LPS Positive_regulation (stimulated) of IL-8
2) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.22 Pain Relevance 0.24
The LPS-induced MIF, IL-6, IL-8, and TNF-?
LPS Positive_regulation (induced) of IL-8
3) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3021874 Disease Relevance 0.29 Pain Relevance 0.25

General Comments

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