INT286386

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Akt2) transport (Akt2) mitochondrion (Akt2)
plasma membrane (Akt2) nucleus (Akt2) carbohydrate metabolic process (Akt2)
Anatomy Link Frequency
myoblast 1
eyes 1
Akt2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2 17.44 Low Low
fibrosis 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
GABAergic 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 2 97.68 Very High Very High Very High
Muscular Atrophy 2 79.20 Quite High
Dwarfism 1 77.12 Quite High
Hypertrophy 1 74.80 Quite High
Myopia 13 55.92 Quite High
Injury 12 22.48 Low Low
INFLAMMATION 2 17.44 Low Low
Birth Weight 9 5.00 Very Low Very Low Very Low
Fibrosis 5 5.00 Very Low Very Low Very Low
Muscle Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, Gonzalez et al. (2004) demonstrated a specific increase in Akt2 protein levels during myoblast differentiation in which Akt kinase activity was correlated with phosphorylation of Ser473 but not Thr308.
Positive_regulation (increase) of Akt2 in myoblast
1) Confidence 0.61 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.40 Pain Relevance 0
Other interesting candidates were Akt2, which was up-regulated after 30 min of deprivation and Mapk8ip3, a neuron specific JNK binding and scaffolding protein that was temporally regulated in the diffuser-treated eyes only.


Positive_regulation (regulated) of Akt2 in eyes
2) Confidence 0.43 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2774458 Disease Relevance 0.06 Pain Relevance 0

General Comments

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