INT28640

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.51
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCR2) plasma membrane (CXCR2) intracellular (CXCR2)
signal transducer activity (CXCR2)
Anatomy Link Frequency
nasopharynx 2
endothelial cells 2
colon 2
neutrophils 2
CXCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 57 99.14 Very High Very High Very High
narcan 23 98.58 Very High Very High Very High
antagonist 41 98.48 Very High Very High Very High
chemokine 118 98.00 Very High Very High Very High
Inflammation 43 94.28 High High
agonist 57 93.12 High High
MU agonist 24 90.88 High High
headache 1 90.56 High High
Enkephalin 16 89.44 High High
cytokine 13 87.32 High High
Disease Link Frequency Relevance Heat
Breast Cancer 267 100.00 Very High Very High Very High
Metastasis 24 99.36 Very High Very High Very High
Cancer 136 99.16 Very High Very High Very High
Gastritis 5 97.84 Very High Very High Very High
Solid Tumor 3 97.40 Very High Very High Very High
Duodenal Ulcer 8 97.28 Very High Very High Very High
Infection 42 96.40 Very High Very High Very High
Stomach Cancer 8 96.20 Very High Very High Very High
Gastroesophageal Reflux Disease 76 95.56 Very High Very High Very High
Granuloma 2 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-8 and CXCR2 overexpression may present a risk factor in the development and progression of solid tumors.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CXCR2 associated with solid tumor
1) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.01 Pain Relevance 0.17
In recent years, several studies have shown that IL-8 and CXCR2 are overexpressed in a range of human cancers including renal, prostate, pancreatic, colon, nasopharyngeal, and gastric cancers [37-41].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CXCR2 in colon associated with cancer and stomach cancer
2) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.91 Pain Relevance 0.30
By considering the expression of IL-8 by breast cancer cells and CXCR2 by large vessel and microvascular endothelial cells [19,20], an autocrine effect for IL-8 and the chemokine receptor CXCR2 has been suggested.
Positive_regulation (considering) of Gene_expression (expression) of CXCR2 in endothelial cells associated with chemokine and breast cancer
3) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.59 Pain Relevance 0.38
Serum levels of soluble IL-2 receptor and lysozyme were increased, and a significant uptake was observed by Ga scintigraphy at the nasopharynx and bilateral hilar lymphnodes.
Positive_regulation (increased) of Gene_expression (levels) of IL-2 receptor in nasopharynx
4) Confidence 0.42 Published 2001 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 11280897 Disease Relevance 0.89 Pain Relevance 0.09
NAL did not affect spontaneous IL-2 receptor expression and it moderately increased PHA-induced IL-2 receptor expression in most of the investigated persons.
Spec (investigated) Positive_regulation (increased) of Gene_expression (expression) of IL-2 receptor associated with narcan
5) Confidence 0.37 Published 1989 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2784786 Disease Relevance 0.37 Pain Relevance 0.71
Importantly, as well as requiring expression of CXCR2, the allosteric effects of the CXCR2 antagonist were produced in a concentration-dependent fashion and with affinity consistent with its occupancy of the CXCR2 orthosteric binding site.
Positive_regulation (requiring) of Gene_expression (expression) of CXCR2 associated with antagonist
6) Confidence 0.18 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.17
Entirely equivalent results were obtained in cells in which the native DOP opioid receptor was expressed constitutively and in which expression of the isolated CXCR2 receptor could be induced.
Positive_regulation (induced) of Gene_expression (expression) of CXCR2 receptor associated with opioid receptor
7) Confidence 0.16 Published 2008 Journal Biochemical Journal Section Abstract Doc Link PMC2474558 Disease Relevance 0.05 Pain Relevance 0.84
We next generated a hCXCR2–C352I G?
Positive_regulation (generated) of Gene_expression (generated) of hCXCR2
8) Confidence 0.15 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.18 Pain Relevance 0.03
But, their expression is dependent on the corresponding expression of their receptors (CXCR1 and CXCR2) on neutrophils.95 IL-8 may influence development of gastritis and duodenal ulcer in patients with H. pylori infection.96,97
Positive_regulation (dependent) of Gene_expression (expression) of CXCR2 in neutrophils associated with duodenal ulcer, gastritis and infection
9) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912116 Disease Relevance 1.53 Pain Relevance 0.21

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