INT286401

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.36
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Akt2) transport (Akt2) mitochondrion (Akt2)
plasma membrane (Akt2) nucleus (Akt2) carbohydrate metabolic process (Akt2)
Anatomy Link Frequency
retina 2
eyes 1
inner surface 1
finger 1
Akt2 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 7 77.72 Quite High
tolerance 12 58.84 Quite High
anesthesia 16 5.00 Very Low Very Low Very Low
GABAergic 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thymoma 2 100.00 Very High Very High Very High
Osteogenic Sarcomas 7 96.68 Very High Very High Very High
Stress 7 88.56 High High
Disorder Of Lipid Metabolism 22 87.00 High High
Shock 9 86.44 High High
Myopia 91 71.52 Quite High
Impaired Glucose Tolerance 12 58.84 Quite High
Injury 14 28.72 Quite Low
Ganglion Cysts 14 22.32 Low Low
Body Weight 12 17.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, a histological study of Akt2 and cFos protein expression in the mouse retina following deprivation seems to be interesting and is planned.
Gene_expression (expression) of Akt2 in retina
1) Confidence 0.72 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.06 Pain Relevance 0
In mammals, Akt2 is expressed in most tissues and organs including the retina, but especially in insulin-responsive tissues [62,63].
Gene_expression (expressed) of Akt2 in retina
2) Confidence 0.72 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.22 Pain Relevance 0.03
Furthermore, it has been shown that Akt2 detaches from the inner surface of the plasma membrane, where it is initially activated, and translocates to the nucleus within 30 min of its activation by growth factors [61].
Gene_expression (detaches) of Akt2 in inner surface
3) Confidence 0.62 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.17 Pain Relevance 0.04
Accordingly, eight potentially interesting genes were selected for validation: early growth response 1 (Egr-1), protein kinase B (Akt2), keratin complex 2, basic, gene 6b (Krt2-6b), myeloblastosis oncogene (Myb), FBJ osteosarcoma oncogene (cFos), ubiquitin specific peptidase 36 (Usp36), zinc finger, MYM-type 4 (Zmym4), and dedicator of cytokinesis 4 (Dock4).
Gene_expression (selected) of Akt2 in finger associated with osteogenic sarcomas
4) Confidence 0.62 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.10 Pain Relevance 0
Baseline expression levels of Akt2, Krt2-6b, Myb, Zmym4, Usp36, and Dock4
Gene_expression (levels) of Akt2
5) Confidence 0.56 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
Baseline expression levels of Akt2, Krt2-6b, Myb, Zmym4, Usp36, and Dock4
Gene_expression (expression) of Akt2
6) Confidence 0.56 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
The mRNA expression of Akt2 and Dock4 increased in both diffuser- and ND filter-treated eyes, however, the increase was more pronounced in the diffuser-treated eyes.
Gene_expression (expression) of Akt2 in eyes
7) Confidence 0.56 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
For example, gene expression of thymoma viral proto-oncogene 2(AKT2), inhibitor of kappaB kinase ?
Gene_expression (expression) of AKT2 associated with thymoma
8) Confidence 0.39 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.41 Pain Relevance 0.03
For example, gene expression of thymoma viral proto-oncogene 2(AKT2), inhibitor of kappaB kinase ?
Gene_expression (expression) of thymoma viral proto-oncogene 2 associated with thymoma
9) Confidence 0.39 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.41 Pain Relevance 0.03

General Comments

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