INT28642

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 60
Total Number 61
Disease Relevance 38.69
Pain Relevance 18.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCR2) plasma membrane (CXCR2) intracellular (CXCR2)
signal transducer activity (CXCR2)
Anatomy Link Frequency
endothelial cells 6
macrophages 2
fibroblasts 2
blood 2
monocyte 2
CXCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 925 100.00 Very High Very High Very High
rheumatoid arthritis 536 100.00 Very High Very High Very High
Dismenorea 6 100.00 Very High Very High Very High
antagonist 252 99.96 Very High Very High Very High
Inflammatory response 79 99.60 Very High Very High Very High
narcan 79 99.44 Very High Very High Very High
Inflammation 496 99.40 Very High Very High Very High
opioid receptor 323 99.14 Very High Very High Very High
cytokine 182 99.06 Very High Very High Very High
abdominal pain 1 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Breast Cancer 1433 100.00 Very High Very High Very High
Rheumatoid Arthritis 538 100.00 Very High Very High Very High
Gastroesophageal Reflux Disease 152 100.00 Very High Very High Very High
Infection 120 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 69 100.00 Very High Very High Very High
Dysmenorrhea 6 100.00 Very High Very High Very High
Cancer 969 99.84 Very High Very High Very High
Atherosclerotic Plaque 16 99.70 Very High Very High Very High
Pulmonary Disease 398 99.60 Very High Very High Very High
INFLAMMATION 618 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequent studies have confirmed the expression of CXCR2, not CXCR1, to be the primary functional chemokine receptor in mediating endothelial cell chemotaxis [18,19].
Gene_expression (expression) of CXCR2 in endothelial cell associated with chemokine
1) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.61 Pain Relevance 0.36
IL-8 and CXCR2 overexpression may present a risk factor in the development and progression of solid tumors.
Gene_expression (overexpression) of CXCR2 associated with solid tumor
2) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.01 Pain Relevance 0.17
Concerning IL-8 receptors, it has been observed that CXCR1 expression was extremely low in breast cancer cells, whereas most of the cells investigated showed a higher expression of CXCR2 [52].
Gene_expression (expression) of CXCR2 associated with breast cancer
3) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.17 Pain Relevance 0.10
In recent years, several studies have shown that IL-8 and CXCR2 are overexpressed in a range of human cancers including renal, prostate, pancreatic, colon, nasopharyngeal, and gastric cancers [37-41].
Gene_expression (overexpressed) of CXCR2 in colon associated with cancer and stomach cancer
4) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.91 Pain Relevance 0.30
The IL-8 receptors CXCR1 and CXCR2 have been reported to be present in a variety of cell types including inflammatory cells, endothelial cells, and fibroblasts [46].
Gene_expression (present) of CXCR2 in fibroblasts associated with inflammation
5) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.45 Pain Relevance 0.21
By considering the expression of IL-8 by breast cancer cells and CXCR2 by large vessel and microvascular endothelial cells [19,20], an autocrine effect for IL-8 and the chemokine receptor CXCR2 has been suggested.
Gene_expression (expression) of CXCR2 in endothelial cells associated with chemokine and breast cancer
6) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.58 Pain Relevance 0.37
For CXCR2 genotyping, 10 ?
Gene_expression (For) of CXCR2
7) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.11 Pain Relevance 0
Only CXCL-8/IL-8 and CXCL-6 specifically bind to CXCR1 whereas all ELR+CXC chemokines bind to CXCR2.
Gene_expression (/) of CXCR2 associated with chemokine
8) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.70 Pain Relevance 0.34
For CXCR2 genotyping, 10 ?
Gene_expression (genotyping) of CXCR2
9) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.11 Pain Relevance 0
Prognostic significance of polymorphism in IL-8 and CXCR2 genes
Gene_expression (genes) of CXCR2
10) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.68 Pain Relevance 0
OBJECTIVE: To investigate the expression of interleukin-8 (IL-8) receptors CXCR1 and CXCR2 in adenomyosis.
Spec (investigate) Gene_expression (expression) of CXCR2 associated with dismenorea
11) Confidence 0.67 Published 2006 Journal Fertil. Steril. Section Abstract Doc Link 16500343 Disease Relevance 0.17 Pain Relevance 0.17
Studies by ourselves and other workers have shown that monocytes/macrophages express several other CXC chemokine receptors in RA, including CXCR1, CXCR2 and CXCR4 [15,16,46].
Gene_expression (express) of CXCR2 in macrophages associated with chemokine and rheumatoid arthritis
12) Confidence 0.66 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.01 Pain Relevance 0.71
CXCR2, expressed on the endothelial cells, is the receptor involved in mediating the angiogenic effects of ELR+CXC chemokines and in particular IL-8.
Gene_expression (expressed) of CXCR2 in endothelial cells associated with chemokine
13) Confidence 0.60 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2895614 Disease Relevance 0.59 Pain Relevance 0.09
Recent studies indicated that CXCR1 and CXCR2 are highly expressed on human microvascular endothelial cells (HMEC) [53].
Gene_expression (expressed) of CXCR2 in endothelial cells
14) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.75 Pain Relevance 0.08
Endothelial cells were found to express CXCR2 in vitro and in vivo, but not CXCR1.
Gene_expression (express) of CXCR2 in Endothelial cells
15) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.38 Pain Relevance 0.11
MAIN OUTCOME MEASURE(S): Microscopic evaluation to assess the presence and localization of CXCR1 and CXCR2 throughout the menstrual cycle in both eutopic endometrial and adenomyotic tissues of women with adenomyosis and compare it with normal endometrium.
Gene_expression (presence) of CXCR2 in endometrium
16) Confidence 0.58 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16500343 Disease Relevance 0.08 Pain Relevance 0
INTERVENTION(S): Tissue sections were immunostained with murine monoclonal anti-human CXCR1 and CXCR2 antibodies.
Gene_expression (immunostained) of CXCR2
17) Confidence 0.58 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16500343 Disease Relevance 0.09 Pain Relevance 0
NAL did not affect spontaneous IL-2 receptor expression and it moderately increased PHA-induced IL-2 receptor expression in most of the investigated persons.
Gene_expression (expression) of IL-2 receptor associated with narcan
18) Confidence 0.57 Published 1989 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2784786 Disease Relevance 0.37 Pain Relevance 0.70
NAL did not affect spontaneous IL-2 receptor expression and it moderately increased PHA-induced IL-2 receptor expression in most of the investigated persons.
Gene_expression (expression) of IL-2 receptor associated with narcan
19) Confidence 0.57 Published 1989 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2784786 Disease Relevance 0.36 Pain Relevance 0.70
Serum levels of soluble IL-2 receptor and lysozyme were increased, and a significant uptake was observed by Ga scintigraphy at the nasopharynx and bilateral hilar lymphnodes.
Gene_expression (levels) of IL-2 receptor in nasopharynx
20) Confidence 0.54 Published 2001 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 11280897 Disease Relevance 0.88 Pain Relevance 0.09

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