INT28643

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Context Info
Confidence 0.11
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.43
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (LBR) small molecule metabolic process (LBR) nucleus (LBR)
DNA binding (LBR)
Anatomy Link Frequency
T lymphocytes 2
LBR (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 14 98.58 Very High Very High Very High
rheumatoid arthritis 99 94.48 High High
Enkephalin 1 67.44 Quite High
antagonist 2 62.32 Quite High
opiate 1 61.00 Quite High
member 8 1 37.92 Quite Low
cytokine 22 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Large Cell Lymphoma 19 100.00 Very High Very High Very High
Rheumatoid Arthritis 99 94.48 High High
Hodgkin's Disease 77 90.48 High High
Lymphatic System Cancer 25 87.60 High High
Duodenal Ulcer 5 82.68 Quite High
Recurrence 2 64.56 Quite High
Skin Cancer 45 56.40 Quite High
Toxicity 12 50.00 Quite Low
Apoptosis 11 50.00 Quite Low
Cancer 48 49.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of IL-12 and IL-18 on PHA/PMA-stimulated PBMCs
Positive_regulation (stimulated) of Gene_expression (Effect) of PHA
1) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.90 Pain Relevance 0.45
NAL did not affect spontaneous IL-2 receptor expression and it moderately increased PHA-induced IL-2 receptor expression in most of the investigated persons.
Spec (investigated) Positive_regulation (increased) of Gene_expression (expression) of PHA-induced associated with narcan
2) Confidence 0.06 Published 1989 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2784786 Disease Relevance 0.37 Pain Relevance 0.71
We have recently developed and characterized 2 novel murine monoclonal antibodies, anti-R23.1 and anti-R24.1, that recognize a 21 kDa cell surface molecule expressed by H/RS and ALCL cells, but not by phytohemagglutinin (PHA) activated CD30+ T lymphocytes [24].
Positive_regulation (activated) of Neg (not) Gene_expression (expressed) of PHA in T lymphocytes associated with anaplastic large cell lymphoma
3) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 1.10 Pain Relevance 0
To measure in vitro IL-10 production by patient's PBMC in response to LPS or PHA stimulation, 1 × 106 cells were thawed, plated in 2 ml AIMV medium in 35 mm petri dishes for 24 hs, and were either untreated or treated with 10 ?
Positive_regulation (response) of Gene_expression (stimulation) of PHA
4) Confidence 0.02 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.06 Pain Relevance 0

General Comments

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