INT286451

Context Info Confidence 0.43 First Reported 2009 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.10 Pain Relevance 0.10

cytosol (AIM2) mitochondrion (AIM2) nucleolus (AIM2) nucleus (AIM2) cytoplasm (AIM2)

AIM2 (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic low back pain 14 100.00 Acupuncture 1 19.64 backache 93 5.00 Pain 34 5.00 complementary and alternative medicine 8 5.00 Sciatica 7 5.00 depression 5 5.00 spinal stenosis 3 5.00 imagery 3 5.00 Inflammation 2 5.00

Disease Link Frequency Relevance Heat Low Back Pain 111 100.00 Pain 31 5.00 Stress 24 5.00 Disease 9 5.00 Anxiety Disorder 8 5.00 Nerve Root Compression 7 5.00 Mental Disorders 7 5.00 Cognitive Disorder 6 5.00 Depression 5 5.00 Cancer 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since assessment of Aim 3, the mediator analysis, is dependent on the results from Aim 1 and Aim 2, the study was not directly powered for Aim 3.

Neg (not) Gene_expression (powered) of Aim 3

1) Confidence 0.43 Published 2010 Journal Trials Section Body Doc Link PMC2864260 Disease Relevance 0 Pain Relevance 0

The primary statistical analyses will directly address Aim 1 (to determine if RM is an effective treatment for chronic low back pain) and Aim 2 (to determine if FSM is more effective than RM).

Gene_expression (address) of Aim 2 associated with low back pain and chronic low back pain

2) Confidence 0.13 Published 2009 Journal Trials Section Body Doc Link PMC2774684 Disease Relevance 0.10 Pain Relevance 0.10

General Comments

This test has worked.