INT286470

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Context Info
Confidence 0.46
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.85
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Itm2b) plasma membrane (Itm2b) nucleus (Itm2b)
Anatomy Link Frequency
plasma 1
Itm2b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 82.72 Quite High
Central nervous system 4 79.92 Quite High
Hippocampus 8 41.56 Quite Low
Spinal cord 16 34.92 Quite Low
cerebral cortex 12 25.76 Quite Low
anesthesia 8 5.00 Very Low Very Low Very Low
Thalamus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 108 97.16 Very High Very High Very High
Alzheimer's Dementia 84 95.84 Very High Very High Very High
Disease 36 93.40 High High
Dementia 180 88.68 High High
INFLAMMATION 4 82.72 Quite High
Neurodegenerative Disease 20 78.16 Quite High
Amyloidosis 16 51.80 Quite High
Cerebral Amyloid Angiopathy 4 36.16 Quite Low
Vascular Disease 8 30.92 Quite Low
Frailty 4 22.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction between the two precursors, APP and BRI2, and possibly between A?
BRI2 Binding (interaction) of
1) Confidence 0.46 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2774945 Disease Relevance 0.84 Pain Relevance 0
Finally, the FDDKI mouse will be instrumental in studying the interaction between mutant BRI2 and APP in vivo and how the Danish mutation affects the inhibitory role of BRI2 on APP processing in vivo.



BRI2 Binding (interaction) of
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 0.35 Pain Relevance 0
It has been shown that BRI2 binds APP in a region comprising the extracellular juxtamembrane domains of both proteins, in a cis fashion [5], [6], [7].
BRI2 Binding (binds) of
3) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 0.97 Pain Relevance 0.08
In fact, only mBRI2 (and not the immature precursor) binds mature APP and inhibits its processing on the plasma membrane and in endocytic compartments [16].
mBRI2 Binding (binds) of in plasma
4) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 0.69 Pain Relevance 0.06

General Comments

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