INT286475

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.83
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITM2B) Golgi apparatus (ITM2B) plasma membrane (ITM2B)
nucleus (ITM2B)
Anatomy Link Frequency
plaque 1
ITM2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 4 97.32 Very High Very High Very High
cerebral cortex 3 92.68 High High
Hippocampus 2 8.32 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
Thalamus 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dementia 45 100.00 Very High Very High Very High
Alzheimer's Dementia 21 99.84 Very High Very High Very High
Ataxia 3 99.80 Very High Very High Very High
Spasticity 1 99.00 Very High Very High Very High
Vascular Disease 2 98.44 Very High Very High Very High
Cognitive Disorder 1 98.28 Very High Very High Very High
Amyloid Plaque 3 96.12 Very High Very High Very High
Neurodegenerative Disease 5 95.16 Very High Very High Very High
Respiratory Distress 1 90.12 High High
Cancer 1 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In FBD, a C-terminal 34 amino acid (aa) peptide of BRI2 accumulates as amyloid, leading to severe amyloid angiopathy of the brain and spinal cord with perivascular amyloid plaque formation, parenchymal plaques affecting the limbic areas, cerebellum, cerebral cortex, neurofibrillary tangles of hippocampal neurons and periventricular white matter changes [11].
Positive_regulation (accumulates) of FBD in plaque associated with dementia, vascular disease, alzheimer's dementia, cerebral cortex, amyloid plaque and spinal cord
1) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 1.83 Pain Relevance 0.10

General Comments

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