INT286476

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 7
Disease Relevance 5.24
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (App, Itm2b) plasma membrane (App, Itm2b) cell adhesion (App)
nucleus (Itm2b) extracellular matrix organization (App) DNA binding (App)
Anatomy Link Frequency
plasma 1
App (Mus musculus)
Itm2b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 7 82.72 Quite High
Central nervous system 7 79.92 Quite High
Hippocampus 14 41.56 Quite Low
Spinal cord 28 34.92 Quite Low
cerebral cortex 21 25.76 Quite Low
anesthesia 14 5.00 Very Low Very Low Very Low
Thalamus 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 147 100.00 Very High Very High Very High
Disease 63 99.40 Very High Very High Very High
Targeted Disruption 189 97.16 Very High Very High Very High
Dementia 315 88.68 High High
Neurodegenerative Disease 35 83.56 Quite High
INFLAMMATION 7 82.72 Quite High
Amyloidosis 28 51.80 Quite High
Cerebral Amyloid Angiopathy 7 37.04 Quite Low
Vascular Disease 14 30.92 Quite Low
Frailty 7 22.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent advances in the understanding of the generation of amyloid in Alzheimer's disease has lead to the finding that BRI2 interacts with the Amyloid Precursor Protein (APP), decreasing the efficiency of APP processing to generate A?
APP Binding (interacts) of BRI2 associated with alzheimer's dementia and disease
1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2774945 Disease Relevance 0.84 Pain Relevance 0
Recent advances in the understanding of the generation of amyloid in Alzheimer's disease has lead to the finding that BRI2 interacts with the Amyloid Precursor Protein (APP), decreasing the efficiency of APP processing to generate A?
Amyloid Precursor Protein Binding (interacts) of BRI2 associated with alzheimer's dementia and disease
2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2774945 Disease Relevance 0.84 Pain Relevance 0
Finally, the FDDKI mouse will be instrumental in studying the interaction between mutant BRI2 and APP in vivo and how the Danish mutation affects the inhibitory role of BRI2 on APP processing in vivo.



APP Binding (interaction) of BRI2
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 0.35 Pain Relevance 0
The interaction between the two precursors, APP and BRI2, and possibly between A?
APP Binding (interaction) of BRI2
4) Confidence 0.35 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2774945 Disease Relevance 0.84 Pain Relevance 0
This new murine mouse model will be important to further understand the interaction between APP and BRI2, and to provide insights into the molecular basis of FDD.



APP Binding (interaction) of BRI2
5) Confidence 0.35 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2774945 Disease Relevance 0.71 Pain Relevance 0
It has been shown that BRI2 binds APP in a region comprising the extracellular juxtamembrane domains of both proteins, in a cis fashion [5], [6], [7].
APP Binding (binds) of BRI2
6) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 0.97 Pain Relevance 0.08
In fact, only mBRI2 (and not the immature precursor) binds mature APP and inhibits its processing on the plasma membrane and in endocytic compartments [16].
APP Binding (binds) of mBRI2 in plasma
7) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2774945 Disease Relevance 0.69 Pain Relevance 0.06

General Comments

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