INT286533

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.40
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh2) plasma membrane (Cdh2) protein complex (Cdh2)
Anatomy Link Frequency
fibroblast 2
Cdh2 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 1 66.76 Quite High
Crohn's disease 9 5.00 Very Low Very Low Very Low
Mechanosensation 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Mechanotransduction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 22 96.16 Very High Very High Very High
Polycystic Kidney Disease 62 95.96 Very High Very High Very High
Apoptosis 29 89.28 High High
Coronary Artery Disease 2 66.64 Quite High
Cystic Kidney Diseases 8 9.44 Low Low
Volume Depletion And Dehydration 1 7.84 Low Low
Death 2 5.96 Low Low
Disease 42 5.00 Very Low Very Low Very Low
Cyst 32 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
But as expression of a dominant negative N-cadherin also interferes with fibroblast growth factor receptor activation and mitogen-activated protein kinase-extracellular signal-regulated kinase (MAPK-ERK) signaling [45], [46], the precise role of E-cadherin in this context remained unclear.
Negative_regulation (interferes) of Gene_expression (expression) of N-cadherin in fibroblast
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.31 Pain Relevance 0.03
As shown in Fig. 2, abnormal adherens and desmosomal junctions were found in ADPKD: intracellular junctions were devoid of desmosomal cadherins and associated proteins, which were sequestered to the cytoplasmic pools, and adherens junctions appeared disrupted, accompanied by a great reduction of Ecadherin expression and partial compensatory expression of N-cadherin [68].
Spec (partial) Negative_regulation (reduction) of Spec (partial) Gene_expression (expression) of N-cadherin associated with polycystic kidney disease
2) Confidence 0.03 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.09 Pain Relevance 0

General Comments

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