INT286536

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.28
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkd1) nucleus (Prkd1) intracellular (Prkd1)
kinase activity (Prkd1) cytoplasm (Prkd1)
Prkd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Mechanosensation 8 5.00 Very Low Very Low Very Low
Somatostatin 8 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Mechanotransduction 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Kidney Disease 124 93.84 High High
Cyst 64 93.36 High High
Syndrome 8 80.20 Quite High
Targeted Disruption 10 78.96 Quite High
Tuberous Sclerosis 2 76.40 Quite High
Cystic Kidney Diseases 16 49.76 Quite Low
Disease 60 43.20 Quite Low
Disease Progression 6 19.60 Low Low
Chronic Renal Failure 4 15.40 Low Low
Hypertension 4 15.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, lowering of Pkd1 expression is sufficient to cause PKD in mice [28].
Positive_regulation (sufficient) of Positive_regulation (cause) of PKD
1) Confidence 0.08 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.83 Pain Relevance 0
The mutations in polycystin-1 may therefore lead to persistent activation of mTOR in PKD.
Spec (may) Positive_regulation (lead) of Positive_regulation (activation) of PKD
2) Confidence 0.08 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.45 Pain Relevance 0

General Comments

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