INT286548

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 4.35
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkd1) nucleus (Prkd1) intracellular (Prkd1)
kinase activity (Prkd1) cytoplasm (Prkd1)
Anatomy Link Frequency
neutrophil 3
cilia 1
cilium 1
Prkd1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 6 79.60 Quite High
cytokine 4 76.64 Quite High
fibrosis 12 68.16 Quite High
metalloproteinase 4 40.32 Quite Low
Somatostatin 24 39.36 Quite Low
Mechanosensation 24 23.64 Low Low
Cholecystokinin 4 18.56 Low Low
imagery 62 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
abdominal pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Kidney Disease 372 93.84 High High
Cyst 192 93.36 High High
Adhesions 114 90.36 High High
Bartter Syndrome 6 88.68 High High
Hyperplasia 6 81.44 Quite High
Cancer 6 79.80 Quite High
Syndrome 24 79.44 Quite High
Targeted Disruption 38 78.96 Quite High
Fungal Infection 76 78.44 Quite High
Disease 180 75.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also provide evidence supporting a mechanism by which SMS regulates neutrophil killing against C. neoformans through the production of DAG and the consequent activation of protein kinase D (PKD).


Positive_regulation (activation) of PKD in neutrophil
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.31 Pain Relevance 0.04
We also provide evidence supporting a mechanism by which SMS regulates neutrophil killing against C. neoformans through the production of DAG and the consequent activation of protein kinase D (PKD).


Positive_regulation (activation) of protein kinase D in neutrophil
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.30 Pain Relevance 0.04
In addition siRNA targeting PKD1, but not that targeting PKD2, inhibited the killing of C. neoformans (Figure 5C), supporting an isoform-specific function.
Positive_regulation (targeting) of PKD1
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.12 Pain Relevance 0
In fact, treatment with benzoxoloazepinolone (CID755673), which at the concentrations used in this study specifically targets PKD1 [46], totally blocked the killing activity of both the media collected from differentiated HL-60 cells (Figure 4B), and from fresh human neutrophils (Figure 11B).
Positive_regulation (targets) of PKD1 in neutrophils
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.14 Pain Relevance 0
In addition, lowering of Pkd1 expression is sufficient to cause PKD in mice [28].
Positive_regulation (cause) of PKD
5) Confidence 0.12 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.82 Pain Relevance 0
Thus, inhibitors of the B-Raf/MEK/ERK pathway may prove to be promising agents for PKD therapy.
Positive_regulation (agents) of PKD
6) Confidence 0.09 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.76 Pain Relevance 0.07
The first example of a therapeutic strategy to promote an increase in cytosolic Ca2+ in PKD has been demonstrated by treatment with triptolide, an active diterpene used in traditional Chinese medicine [115].
Positive_regulation (increase) of PKD
7) Confidence 0.09 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.66 Pain Relevance 0
Polycystins, fibrocystin and numerous other proteins or cystoproteins such as nephrocystin-1, -3, -4, -5, inversin, ALMS1, OFD1, BBS1-8, cystin, polaris and Nek8, which cause PKD in humans and animals, were recently discovered in a distinct subcellular compartment, the primary cilium [10, 74, 75].
Positive_regulation (cause) of PKD in cilium
8) Confidence 0.09 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.72 Pain Relevance 0
The mutations in polycystin-1 may therefore lead to persistent activation of mTOR in PKD.
Positive_regulation (activation) of PKD
9) Confidence 0.08 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.45 Pain Relevance 0
As we discussed previously, a number of cystoproteins causing PKD in humans and animals are expressed, at least partially, in cilia or the basal body of the cilia.
Positive_regulation (causing) of PKD in cilia
10) Confidence 0.08 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.07 Pain Relevance 0

General Comments

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