INT286554

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.77
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pkd1) plasma membrane (Pkd1) nucleus (Pkd1)
cilium (Pkd1)
Pkd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Mechanosensation 12 5.00 Very Low Very Low Very Low
Somatostatin 12 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Mechanotransduction 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cyst 96 96.68 Very High Very High Very High
Polycystic Kidney Disease 186 95.36 Very High Very High Very High
Disease 90 91.28 High High
Targeted Disruption 15 84.72 Quite High
Disease Progression 9 20.84 Low Low
Chronic Renal Failure 6 16.64 Low Low
Hypertension 6 16.28 Low Low
Adhesions 57 5.00 Very Low Very Low Very Low
Apoptosis 51 5.00 Very Low Very Low Very Low
Cystic Kidney Diseases 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, lowering of Pkd1 expression is sufficient to cause PKD in mice [28].
Negative_regulation (lowering) of Gene_expression (expression) of Pkd1
1) Confidence 0.35 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.82 Pain Relevance 0
It is possible that reduced expression of the normal PKD1 allele below a critical level due to genetic or environmental factors may lead to cyst formation in the kidneys of ADPKD patients [28].
Negative_regulation (reduced) of Gene_expression (expression) of PKD1 associated with polycystic kidney disease and cyst
2) Confidence 0.26 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.86 Pain Relevance 0
Further analysis has shown that polycystin-1 expression inhibits Cdk2 and induces p21waf1.
Negative_regulation (inhibits) of Gene_expression (expression) of polycystin-1
3) Confidence 0.26 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.09 Pain Relevance 0

General Comments

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