INT286562

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pkd1, Ctnnb1) plasma membrane (Pkd1, Ctnnb1) cell differentiation (Ctnnb1)
Golgi apparatus (Pkd1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
Anatomy Link Frequency
tail 2
Pkd1 (Mus musculus)
Ctnnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Mechanosensation 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Mechanotransduction 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Kidney Diseases 8 86.64 High High
Polycystic Kidney Disease 62 70.72 Quite High
Targeted Disruption 5 68.88 Quite High
Cyst 32 59.52 Quite High
Disease 30 56.28 Quite High
Apoptosis 17 15.08 Low Low
Congenital Anomalies 6 12.56 Low Low
Tuberous Sclerosis 1 10.08 Low Low
Adhesions 19 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated Wnt signaling was initially implicated in PKD through studies demonstrating that overexpression of the cytoplasmic tail of polycystin-1 stabilizes endogenous beta-catenin and stimulates TCF-dependent gene transcription in vitro [90].
Gene_expression (overexpression) of polycystin-1 in tail Positive_regulation (stabilizes) of beta-catenin
1) Confidence 0.02 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.52 Pain Relevance 0

General Comments

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